Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
NCT ID: NCT00874432
Last Updated: 2020-10-27
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE2
43 participants
INTERVENTIONAL
2009-01-31
2011-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Chronic Kidney Disease-ACE-I
ace inhibitor
lisinopril
1 x 40 mg per day
Chronic Kidney Disease
angiotensin converting enzyme inhibitor
Active comparator in chronic kidney disease and age matched control will take 1x40mg per day Placebo comparator in chronic kidney disease and age matched control will take 1 placebo pill per day
Age matched control-ACE-I
ace-inhibitor
lisinopril
1 x 40 mg per day
Age matched control
Placebo
angiotensin converting enzyme inhibitor
Active comparator in chronic kidney disease and age matched control will take 1x40mg per day Placebo comparator in chronic kidney disease and age matched control will take 1 placebo pill per day
Interventions
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angiotensin converting enzyme inhibitor
Active comparator in chronic kidney disease and age matched control will take 1x40mg per day Placebo comparator in chronic kidney disease and age matched control will take 1 placebo pill per day
lisinopril
1 x 40 mg per day
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* BP 120/80 or higher \*(bps will be checked weekly first 4 weeks to ensure \< 130/80 - IF bp remains \> 130/80 we will administer other bp meds per JNC VII guidelines)
* CKD stage 3 (GFR 30 - 59 ml/min) for CKD group; no CKD for control group
Exclusion Criteria
* Serum potassium \> 5.2 meq/L
* Known allergy or hypersensitivity to ACE inhibitor or ARB
* Female of childbearing age not practicing contraception
* Current treatment with an Angiotensin Converting Enzyme Inhibitors (ACE-I) or Angiotensin-Receptor Blockers (ARB) (Note: can participate if on ACE-I after 6 week washout period)
* History of ACE-I induced angioedema
* History of angioedema, hereditary or idiopathic
* Persons lacking consent capacity
* 500 mg/dL proteinuria on 2 consecutive spot urine protein/creat ratios
60 Years
89 Years
ALL
Yes
Sponsors
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University of Wisconsin, Madison
OTHER
Responsible Party
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Principal Investigators
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Arjang Djamali, MD
Role: PRINCIPAL_INVESTIGATOR
University of Wisconsin-Madison School of Medicine and Public Health
Laura Maursetter, DO
Role: STUDY_DIRECTOR
University of Wisconsin, Madison
Locations
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University of Wisconsin-Madison Hospitals and Clinics
Madison, Wisconsin, United States
Countries
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References
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Other Identifiers
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A534280
Identifier Type: OTHER
Identifier Source: secondary_id
SMPH/MEDICINE/NEPHROLOGY
Identifier Type: OTHER
Identifier Source: secondary_id
H-2008-0221
Identifier Type: -
Identifier Source: org_study_id