The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-28

Study Completion Date

2023-12-12

Brief Summary

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Recent evidence suggests ketamine may attenuate harmful cellular cascades taking place after brain injury that result in permanent damage. The investigators are interested in researching the application of this in the setting of cardiac arrest. Following cardiac arrest, the brain is deprived oxygen for a period of time, leading to the imitation of these harmful cellular processes. The investigators hypothesize that patients who receive ketamine as part of their standard sedation procedures during cardiac arrest treatment have better neurological functioning compared to those who do not.

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Detailed Description

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Conditions

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Cardiac Arrest, Out-Of-Hospital Ketamine Neurologic Manifestations

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Ketamine Arm

Patients randomized to the ketamine arm will receive ketamine as part of their sedation medications during their cardiac arrest treatment

Group Type EXPERIMENTAL

Ketamine Hydrochloride

Intervention Type DRUG

Parenteral General Anesthetic

Control Arm

Patients randomized to the control arm will not receive ketamine as part of their sedation medications during their cardiac arrest treatment.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Ketamine Hydrochloride

Parenteral General Anesthetic

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* All out-of-hospital cardiac arrests (OHCA) with a "shockable rhythm" (ventricular fibrillation, pulseless ventricular tachycardia) that present to the Royal Columbian Hospital. The patient may be either in active cardiac arrest with shockable rhythm or may have achieved Return of Spontaneous Circulation (ROSC).
* Over 19 years of age
* Patients requiring sedation based on the assessment of the resuscitating physician.

Exclusion Criteria

* Any other type of cardiac arrest
* Any history of previous, pre-existing neurological deficit
* Started on Extracorporeal Membrane Oxygenation (ECMO)
* Duration of cardiac arrest without ROSC is greater than 30 consecutive minutes
* Known contraindication or hypersensitivity to ketamine
* Awake patient or no standard sedation or no intubation required
* Inability to obtain deferred consent
* Currently enrolled in any other research study involving drugs or devices
* Patients who are pregnant
* Patients who are prisoners
* Patients residing in Long Term Care (LTC) facilities

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No