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Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder

NCT ID: NCT04335175

Last Updated: 2022-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-14

Study Completion Date

2022-02-28

Brief Summary

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This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? Patients with TS, patients with OCD, and healthy controls will complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and quality of life.

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Detailed Description

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Tourette syndrome (TS) is a neurodevelopmental disorder affecting 1% of school-aged children, with one-third of patients suffering persistent tics into adulthood. Obsessive-compulsive disorder (OCD) is a common comorbidity with TS. Individuals with either TS or OCD frequently exhibit sensory dysregulation, manifesting as heightened awareness of internal and external stimuli. For patients with OCD, sensory dysregulation has been linked to obsessive-compulsive symptoms and is an important consideration in treatment strategies. Sensory dysregulation remains largely unexplored in TS, but preliminary data suggests it is dissociable from tics, linked with obsessive-compulsive symptoms, and associated with poorer quality of life (QOL). This study seeks to address two key questions related to sensory dysregulation in TS and OCD: 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? To do so, we will recruit patients with TS, patients with OCD, and healthy controls to complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and QOL. Addressing these knowledge gaps will enhance our understanding of bothersome sensory symptoms in TS and OCD, shed light on clinical overlap and/or distinctions between these commonly co-occurring psychiatric diagnoses, and clarify QOL impact and the potential need for more direct targeting of these symptoms.

Conditions

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Tourette Syndrome Obsessive-Compulsive Disorder Sensory Disorders

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Tourette Syndrome

Individuals previously diagnosed with Tourette syndrome (TS). Participants must be 18 years of age or older.

None - observational study

Intervention Type OTHER

None - observational study

Obsessive Compulsive Disorder

Individuals previously diagnosed with obsessive compulsive disorder (OCD). Participants must be 18 years of age or older.

None - observational study

Intervention Type OTHER

None - observational study

Healthy Controls

Individuals with no past or current neurologic or psychiatric illness. Participants must be 18 years of age or older.

None - observational study

Intervention Type OTHER

None - observational study

Interventions

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None - observational study

None - observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age 18 years or older
* previous diagnosis of Tourette syndrome and/or obsessive compulsive disorder


\- 18 years of age or older

Exclusion Criteria

\- none


\- history of any neurologic or psychiatric diagnoses
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Vanderbilt University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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David Isaacs

Assistant Professor of Neurology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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David Isaacs, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Vanderbilt University Medical Center

Locations

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Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

Countries

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United States

Other Identifiers

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200502

Identifier Type: -

Identifier Source: org_study_id

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