Allergen Provocations- HCA Children's Hospital

NCT ID: NCT04331522

Last Updated: 2025-07-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

8000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-01

Study Completion Date

2039-10-31

Brief Summary

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A prospective study of all allergen provocations performed in children at the Hans Christian Andersen Children's Hospital.

Detailed Description

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The purpose of the study is to investigate the impact of co-morbidities, history, and allergen tests on the outcome of allergen provocation tests.

Subjects are children aged 0-18 years old investigated for allergy to foods or antibiotics. Data entered in the database are demographics, co-morbidities, symptoms, SPT, specific IgE and details of the allergen provocations.

Conditions

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Allergy in Children

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Antibiotics

Children aged 0-18 years investigated for allergy to antibiotics

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Milk

Children aged 0-18 years investigated for allergy to milk

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Egg

Children aged 0-18 years investigated for allergy to egg

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Peanut

Children aged 0-18 years investigated for allergy to peanut

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Hazelnut

Children aged 0-18 years investigated for allergy to hazelnut

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Sesame

Children aged 0-18 years investigated for allergy to sesame

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Wheat

Children aged 0-18 years investigated for allergy to wheat

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

walnut

Children aged 0-18 years investigated for allergy to walnut

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

cashew

Children aged 0-18 years investigated for allergy to cashew

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Pistachio

Children aged 0-18 years investigated for allergy to pistachio

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Almond

Children aged 0-18 years investigated for allergy to almond

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Soy

Children aged 0-18 years investigated for allergy to soy

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Fish

Children aged 0-18 years investigated for allergy to fish

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Shellfish

Children aged 0-18 years investigated for allergy to shellfish

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Poppy seed

Children aged 0-18 years investigated for allergy to poppy seed

Oral provocation test

Intervention Type DIAGNOSTIC_TEST

Titrated provocation with allergen

Interventions

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Oral provocation test

Titrated provocation with allergen

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

clinical suspicion of allergy to foods or antibiotics informed concent -

Exclusion Criteria

\-
Minimum Eligible Age

0 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Josefine Gradman

OTHER

Sponsor Role lead

Responsible Party

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Josefine Gradman

Consultant, phd

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Hans Christian Andersen Children's Hospital

Odense, Odense C, Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Josefine Gradman, phd

Role: CONTACT

+4529241375

Susanne Halken, DMSc

Role: CONTACT

Facility Contacts

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Josefine Gradman

Role: primary

004529241375

References

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Gradman J, Petersen BT, Halken S. Oral food challenge with raw egg: Sixty-minute- compared with 30-minute dosing interval. Clin Exp Allergy. 2022 Sep;52(9):1114-1117. doi: 10.1111/cea.14187. Epub 2022 Jul 4. No abstract available.

Reference Type DERIVED
PMID: 35719001 (View on PubMed)

Petersen BT, Gradman J. Prospective study of 5-day challenge with penicillins in children. BMJ Paediatr Open. 2020 Aug 4;4(1):e000734. doi: 10.1136/bmjpo-2020-000734. eCollection 2020.

Reference Type DERIVED
PMID: 32818157 (View on PubMed)

Other Identifiers

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HCA-AP

Identifier Type: -

Identifier Source: org_study_id

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