Parasternal Block for Cardiac Surgery

NCT ID: NCT04319588

Last Updated: 2023-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

126 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-06

Study Completion Date

2020-05-19

Brief Summary

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This study examine the effect of Parasternal Intercostal Nerve Blocks with local anesthetic on pain control in patients undergoing non-emergent cardiac surgery in a prospective controlled trial. Half of participants will receive General Anesthesia combined to parasternal block while the other half receive only General Anesthesia.

Detailed Description

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60 patients undergoing elective cardiac surgery will be enrolled and divided into two groups:

1. Interventional (parasternal group)
2. Case control group The "parasternal group" of patients will receive the pre-operative parasternal block (20 ml of 0.5% Ropivacaine per side) in association with infiltration with local anesthetic of access to thoracic drainage (drainage infiltration with 20 ml of 0.25% Ropivacaine) at the end of the intervention combined to General Anesthesia.

The "case control group" will only receive drainage infiltration with local anesthetic and standard intraoperative management with opioids.

Conditions

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Cardiac Disease Analgesia Acute Pain Postoperative Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Parasternal Group

The "parasternal group" of patients will receive the pre-operative parasternal block (20 ml of 0.5% Ropivacaine per side) in association with infiltration with local anesthetic of access to thoracic drainage (drainage infiltration with 20 ml of 0.25% Ropivacaine) at the end of the intervention combined to General Anesthesia.

Group Type EXPERIMENTAL

Parasternal Block+ Infiltration with local anesthetic of access to thoracic drainage

Intervention Type PROCEDURE

After induction of general anesthesia we will perform an ultrasound-guided Parasternal Block in association with infiltration with local anesthetic of access to thoracic drainage at the end of the intervention.

Case control group

The "case control group" will only receive drainage infiltration with local anesthetic and standard intraoperative management with opioids.

Group Type ACTIVE_COMPARATOR

Infiltration with local anesthetic of access to thoracic drainage

Intervention Type PROCEDURE

Infiltration with local anesthetic of access to thoracic drainage at the end of the intervention.

Interventions

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Parasternal Block+ Infiltration with local anesthetic of access to thoracic drainage

After induction of general anesthesia we will perform an ultrasound-guided Parasternal Block in association with infiltration with local anesthetic of access to thoracic drainage at the end of the intervention.

Intervention Type PROCEDURE

Infiltration with local anesthetic of access to thoracic drainage

Infiltration with local anesthetic of access to thoracic drainage at the end of the intervention.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing elective cardiac surgery
* Age over 18 years
* ASA I-IV
* Approval by the patient of informed consent

Exclusion Criteria

* Allergy to local anesthetics
* Puncture site infection
* Lack of signing of informed consent
* Weight \<30 Kg
* Age \<18 years
* Emergency interventions
* ASA \> IV
* Sternal dehiscences
* Dementia (for difficulties in managing weaning from mechanical ventilation and pain)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Campus Bio-Medico University

OTHER

Sponsor Role lead

Responsible Party

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Giulia Nonnis

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Campus Biomedico University

Rome, Roma, Italy

Site Status

Countries

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Italy

References

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Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, Carter T, Cassidy CL, Chittenden EH, Degenhardt E, Griffith S, Manworren R, McCarberg B, Montgomery R, Murphy J, Perkal MF, Suresh S, Sluka K, Strassels S, Thirlby R, Viscusi E, Walco GA, Warner L, Weisman SJ, Wu CL. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016 Feb;17(2):131-57. doi: 10.1016/j.jpain.2015.12.008.

Reference Type RESULT
PMID: 26827847 (View on PubMed)

Other Identifiers

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20/20 PAR ComEt CBM

Identifier Type: -

Identifier Source: org_study_id

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