Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Intercostal Nerve Block for Chronic Post-thoracotomy Pain

NCT ID: NCT05556122

Last Updated: 2022-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-04

Study Completion Date

2022-12-30

Brief Summary

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The patients were divided into two groups by random number method: GroupRD1 group and GroupRD2 group were given general anesthesia and intercostal nerve block.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml.

Detailed Description

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The RD1 group received ultrasound-guided intercostal nerve block at the incision before anesthesia induction, and the RD2 group received ultrasound-guided intercostal nerve block at the lateral costal Angle before anesthesia induction.

Conditions

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Nerve Block

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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intercostal nerve block at the incision

General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

Group Type EXPERIMENTAL

intercostal nerve block

Intervention Type OTHER

General anesthesia and intercostal nerve block were performed. The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

ropivacaine + compound betamethasone

Intervention Type DRUG

The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

lateral intercostal nerve block at costal angle

General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

Group Type ACTIVE_COMPARATOR

lateral intercostal nerve block

Intervention Type OTHER

lateral intercostal nerve block

ropivacaine + compound betamethasone

Intervention Type DRUG

The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

Interventions

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intercostal nerve block

General anesthesia and intercostal nerve block were performed. The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

Intervention Type OTHER

lateral intercostal nerve block

lateral intercostal nerve block

Intervention Type OTHER

ropivacaine + compound betamethasone

The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. 18-70 years old
2. ASA grade I-III
3. BMI: 18.5-28kg/m2
4. Type of surgery: elective thoracoscopic lung mass resection
5. Informed consent has been signed by the patient and/or family members

Exclusion Criteria

1. game anesthesia or sugar cortical hormone drugs allergic
2. preoperative use of opioid medicines
3. serious blood coagulation dysfunction
4. serious heart, lung, liver and renal insufficiency
5. put, chemotherapy, and glucocorticoid immunosuppressive therapy history or diseases of the immune system
6. peptic ulcer
7. newly gastrointestinal surgery
8. has a history of thoracic surgery
9. is the central nervous system disease
10. Other glucocorticoids should be used with caution in patients such as fractures, wound repair, corneal ulcers, hyperadrenocortical disease, diabetes mellitus, pregnant women, etc.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Affiliated Hospital of Nantong University

OTHER

Sponsor Role lead

Responsible Party

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Yibin Qin

associate chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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DingYing Ge

Role: STUDY_DIRECTOR

Affiliated Hospital of Nantong University

Locations

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YiBinQin

Nantong, Jiangsu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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YiBin Qin

Role: CONTACT

13815212600

Facility Contacts

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DingYing Ge

Role: primary

19851303726

Other Identifiers

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2022-K107-01

Identifier Type: -

Identifier Source: org_study_id

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