Observational, Postmarketing Surveillance Study of Spinraza Injection (Nusinersen Sodium)

NCT ID: NCT04317794

Last Updated: 2025-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

74 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-07-02

Study Completion Date

2027-02-05

Brief Summary

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The primary objective is to evaluate the safety of nusinersen sodium injection in the postmarketing setting in Korea. The secondary objective is to evaluate the effectiveness of nusinersen sodium injection in the postmarketing setting in Korea.

Detailed Description

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Conditions

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Muscular Atrophy, Spinal

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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All Participants

Participants who were prescribed with nusinersen sodium injection in Korea according to local marketing authorization.

Nusinersen Sodium Injection

Intervention Type DRUG

Administered as specified in the treatment arm.

Interventions

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Nusinersen Sodium Injection

Administered as specified in the treatment arm.

Intervention Type DRUG

Other Intervention Names

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BIIB058 ISIS 396443 Spinraza

Eligibility Criteria

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Inclusion Criteria

* Currently receiving or about to initiate treatment with commercial Spinraza in the postmarketing setting
* Genetic documentation of 5q-linked SMA

Exclusion Criteria

* Hypersensitivity to the active substance or any of the excipients of Spinraza
* Ongoing participation or participation within 6 months or 5 half-lives of the agent (whichever is longer) of enrollment in other interventional clinical trials for the treatment of SMA
* Inability to comply with study requirements
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biogen

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Biogen

Locations

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Pusan Natioanl University Hospital

Busan, , South Korea

Site Status

Samsung Changwon Hospital

Changwon, , South Korea

Site Status

Chungbuk National University Hospital

Cheongju-si, , South Korea

Site Status

Kyungpook National University Hospital

Daegu, , South Korea

Site Status

Yeungnam University Hospital

Daegu, , South Korea

Site Status

Chungnam National University Hospital

Daejeon, , South Korea

Site Status

Chonnam National University Hospital

Gwangju, , South Korea

Site Status

Chonbuk National University Hospital

Jeonju, , South Korea

Site Status

Severance Hospital

Seoul, , South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Korea university Anam Hospital

Seoul, , South Korea

Site Status

Korea University Guro Hospital

Seoul, , South Korea

Site Status

Samsung Medical Center

Seoul, , South Korea

Site Status

Seoul Natioanl University Hospital

Seoul, , South Korea

Site Status

Severance Hospital, Yonsei University Health System

Seoul, , South Korea

Site Status

Pusan National University Yangsan Hospital

Yangsan, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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232SM403

Identifier Type: -

Identifier Source: org_study_id

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