Non-Interventional, Postmarketing Surveillance Study of Nusinersen Sodium Injection

NCT ID: NCT04419233

Last Updated: 2023-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-18

Study Completion Date

2023-11-21

Brief Summary

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The primary objective of this study is to evaluate the safety of nusinersen sodium injection in the postmarketing setting in China.The secondary objectives are to collect data on the efficacy and the pharmacokinetics of nusinersen sodium injection in the post-marketing setting in China.

Detailed Description

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Conditions

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Muscular Atrophy, Spinal

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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All Participants

Participants with 5q SMA and who were prescribed with nusinersen sodium injection in China according to the local marketing authorization.

Nusinersen Sodium Injection

Intervention Type DRUG

Administered as specified in the treatment arm.

Interventions

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Nusinersen Sodium Injection

Administered as specified in the treatment arm.

Intervention Type DRUG

Other Intervention Names

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BIIB058 ISIS 396443 Spinraza

Eligibility Criteria

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Inclusion Criteria

* Ability of the participant or his/her legally authorized representative (e.g., parent or legal guardian), as appropriate and applicable, to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information in accordance with national and local subject privacy regulations.
* The decision to newly prescribe nusinersen sodium injection according to the local marketing authorization, including documentation of 5q SMA diagnosis, has been made by the Investigator and agreed to by the participant (or legally authorized representative)

Exclusion Criteria

* Hypersensitivity to the active substance or any of the excipients of nusinersen sodium injection.
* Current or past administration of nusinersen sodium injection, in either a commercial or a clinical study setting.
* Other unspecified reasons that, in the opinion of the Investigator or the Sponsor, make the participant unsuitable for enrollment.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biogen

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Biogen

Locations

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Research Site

Xicheng, Beijing Municipality, China

Site Status

Research Site

Fuzhou, Fujian, China

Site Status

Research Site

Guangzhou, Guangdong, China

Site Status

Research Site

Suzhou, Jiangsu, China

Site Status

Research Site

Changchun, Jilin, China

Site Status

Research Site

Minhang, Shanghai Municipality, China

Site Status

Research Site

Chengdu, Sichuan, China

Site Status

Research Site

Beijing, Xicheng, China

Site Status

Research Site

Hangzhou, Zhejiang, China

Site Status

Countries

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China

References

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Jiang Y, Wang Y, Xiong H, Li W, Luo R, Chen W, Yin F, Lu J, Liang J, Chen WJ, Lu X, Wang H, Tang J, Monine M, Makepeace C, Jin X, Foster R, Chin R, Berger Z. A Post-Marketing Surveillance Study of Nusinersen for Spinal Muscular Atrophy in Routine Medical Practice in China: Interim Results. Adv Ther. 2024 Jul;41(7):2743-2756. doi: 10.1007/s12325-024-02852-7. Epub 2024 May 9.

Reference Type DERIVED
PMID: 38722537 (View on PubMed)

Other Identifiers

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232SM402

Identifier Type: -

Identifier Source: org_study_id