Music Therapy for Pain Management for Minor Procedures in Neonates.

NCT ID: NCT04313179

Last Updated: 2021-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-09

Study Completion Date

2020-02-25

Brief Summary

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The aim of this study is to assess the effectiveness and safety of music therapy as adjuvant therapy for pain management in newborns undergoing minor painful procedures. It is a prospective study and we plan to enroll 200 healthy full term newborns undergoing minor procedures (heel pricks). They will be randomly assigned to either control or music group. Those in music group will receive recorded Mozart lullaby music. Pain will be assessed using NIPS (Neonatal Infant Pain Scale) scoring tool. The potential benefit of the study would be identifying music a safe and efficient adjuvant therapy for pain management in newborns.

Detailed Description

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This randomized, controlled, double blinded, clinical trial will include full term neonates undergoing painful minor procedures (heel pricks) in the Nursery unit of Lincoln Medical and Mental Health Center.

One of the investigators involved in the study will obtain consent from the legal guardian and enroll the participants. All infants, regardless of the group that they are assigned, will receive similar standard non-pharmacologic method of pain relief which is 0.5 ml of 24% Sucrose, 2 minutes before undergoing heel prick. Pacifiers will be avoided to avoid potential confounding.

Subjects will be randomized into two different groups. Group A, music intervention group and group B, control group. In the music intervention group, a recorded instrumental lullaby music track called "Deep Sleep" from "Bedtime Mozart: Classical Lullabies for Babies", will be played for the neonates through smart phone speakers (maximum sound up to 60 A dB), starting 20 minutes before the heel prick, continuing through the procedure and for 5 minutes after the procedure. This music track has been selected based on previous research studies that showed effectiveness in neonatal pain management.

An investigator involved in the study will place the baby in a bassinet in a quite, dim lighted room. He/She will play the music for those babies in the music group and will NOT assess the NIPS. Another investigator wearing active noise cancelling Bluetooth headphones (for blinding) will enter the room at 5 minutes prior to the procedure and assess the NIPS at appropriate intervals: 5 minutes prior and at 1-minute interval during and after the procedure for 5 minutes. NIPS will be compared using appropriate statistical methods.

Conditions

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Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Music group

"Deep Sleep" music track from "Bedtime Mozart: Classical Lullabies for Babies", played through smart phone speakers, at maximum sound up to 45 dB, starting 20 minutes before the heel prick procedure, continuing through the procedure and for 5 minutes after the procedure. Also given 0.5 ml of 24% Sucrose given 2 minutes prior to heel prick procedure for baseline pain relief.

Group Type EXPERIMENTAL

Music therapy

Intervention Type OTHER

Mozart lullaby music

Sucrose

Intervention Type OTHER

0.5 ml of 24% Sucrose

Placebo group

0.5 ml of 24% Sucrose given 2 minutes prior to heel prick procedure. No music played.

Group Type PLACEBO_COMPARATOR

Sucrose

Intervention Type OTHER

0.5 ml of 24% Sucrose

Interventions

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Music therapy

Mozart lullaby music

Intervention Type OTHER

Sucrose

0.5 ml of 24% Sucrose

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* \>37 weeks gestation babies

Exclusion Criteria

* \<37 weeks gestation babies
* Major congenital anomalies
* Failed hearing screen
Minimum Eligible Age

37 Weeks

Maximum Eligible Age

42 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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New York City Health and Hospitals Corporation

OTHER

Sponsor Role lead

Responsible Party

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Pratiba Ankola

MD, Neonatologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Prathiba Ankola, MD

Role: PRINCIPAL_INVESTIGATOR

Lincoln Medical Center

Locations

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Lincoln Medical Center

The Bronx, New York, United States

Site Status

Countries

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United States

References

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Standley J. Music therapy research in the NICU: an updated meta-analysis. Neonatal Netw. 2012 Sep-Oct;31(5):311-6. doi: 10.1891/0730-0832.31.5.311.

Reference Type BACKGROUND
PMID: 22908052 (View on PubMed)

Bieleninik L, Ghetti C, Gold C. Music Therapy for Preterm Infants and Their Parents: A Meta-analysis. Pediatrics. 2016 Sep;138(3):e20160971. doi: 10.1542/peds.2016-0971. Epub 2016 Aug 25.

Reference Type BACKGROUND
PMID: 27561729 (View on PubMed)

Shukla VV, Bansal S, Nimbalkar A, Chapla A, Phatak A, Patel D, Nimbalkar S. Pain Control Interventions in Preterm Neonates: A Randomized Controlled Trial. Indian Pediatr. 2018 Apr 15;55(4):292-296. Epub 2018 Feb 9.

Reference Type BACKGROUND
PMID: 29428919 (View on PubMed)

Other Identifiers

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IRB#18-026

Identifier Type: -

Identifier Source: org_study_id

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