Regional Anesthesia for Head and Neck Reconstruction

NCT ID: NCT04304716

Last Updated: 2020-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE4

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-31

Study Completion Date

2021-03-31

Brief Summary

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By utilizing regional anesthesia blocks at the surgery tissue donor sites, it can potentially reduce post-operative pain while also reducing the use of opioids. It can aim to measure the reduction in opioid use, reduction in pain scores, patient satisfaction, and because there is not a current protocol established for regional anesthesia use for free flap reconstruction, and we aim to standardize the procedure.

Detailed Description

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Conditions

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Pain, Postoperative

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Fibular free flap-Block performed

For subjects in the experimental/regional anesthesia group for anterolateral thigh or radial forearm free flap, during the procedure a catheter will be placed into the donor site (leg or arm), wound bed

Group Type ACTIVE_COMPARATOR

Regional Anesthesia

Intervention Type DRUG

Block performed is an indwelling wound bed or popliteal catheter placed intraoperatively

Anterolateral thigh free flap-Block performed

Description: For subjects in the experimental/regional anesthesia group for anterolateral thigh or radial forearm free flap, during the procedure a catheter will be placed into the donor site (leg or arm), wound bed

Group Type ACTIVE_COMPARATOR

Regional Anesthesia

Intervention Type DRUG

Block performed is an indwelling wound bed or popliteal catheter placed intraoperatively

Radial forearm free flap-Block performed

Description: For subjects in the experimental/regional anesthesia group for anterolateral thigh or radial forearm free flap, during the procedure a catheter will be placed into the donor site (leg or arm), wound bed

Group Type ACTIVE_COMPARATOR

Regional Anesthesia

Intervention Type DRUG

Block performed is an indwelling wound bed or popliteal catheter placed intraoperatively

Fibular free flap -Control

No additional procedures beyond the normal standard of care will be performed

Group Type NO_INTERVENTION

No interventions assigned to this group

Anterolateral thigh free flap-Control

No additional procedures beyond the normal standard of care will be performed

Group Type NO_INTERVENTION

No interventions assigned to this group

Radial forearm free flap-Control

No additional procedures beyond the normal standard of care will be performed

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Regional Anesthesia

Block performed is an indwelling wound bed or popliteal catheter placed intraoperatively

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects undergoing microvascular fibula free flap reconstruction of the head and neck
* Subjects undergoing primary reconstruction for both benign and malignant etiology

Exclusion Criteria

* Pregnant women
* Subjects with true allergies to the study drugs, reporting anaphylaxis in the past
* Subjects undergoing reconstruction with more than 1 free flap
* Subjects undergoing secondary reconstructions
* Subjects undergoing surgery for osteonecrosis
* History of enrollment in a pain management program
* Any subject currently enrolled in pain management, or currently taking long acting opioids such as methadone or oxycontin
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rui Fernandes, MD, DMD

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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University of Florida

Jacksonville, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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IRB201903261

Identifier Type: -

Identifier Source: org_study_id

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