Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2022-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

At present, functional imaging studies have suggested that the Geschwind's territory (the inferior parietal lobe) is an important language area. It is the hub for semantics and phonetic language processing. However, the type and mechanism of aphasia after injury of Geschwind's territory and the subsequent recovery of language are still unclear. In our study based on brain injury model of brain arteriovenous malformation (BAVMs) resection, investigators found that the incidence of aphasia was higher after the injury of Geschwind's territory than after injury of the classical language area, and the type of aphasia was complicated, while the recovery rate of language disorder was high during follow-up. Investigators hypothesized that the type of aphasia may be associated with the type of brain connectivity damaged, and that reorganization of brain connections and brain network promote the recovery of language function. In this study, we aim to investigate the types of aphasia and their corresponding brain network changes after the resection of BAVMs located in the Geschwind's territory. Investigators will evaluate language function and collect multimodality images of the patients before resection of the lesions, as well as 7 days, 3 months and 6 months afterwards. In addition, the anatomical brain connectivity and brain network will also be analyzed. Our research will not only be a meaningful exploration for mechanisms of human language function damage and reorganization, but will also provide an important basis for the protection of brain function in neurosurgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Enhanced Recovery After Surgery Using TMS on Cerebellar Language Area for Brain Tumor Patients

NCT03974659

Cerebellar Function Transcranial Magnetic Stimulation Language Disorders

UNKNOWN NA

Multimodal Brain Imaging Study

NCT04960540

Amyotrophic Lateral Sclerosis

UNKNOWN

Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke

NCT06458153

Stroke Cerebellum

RECRUITING NA

Cognitive Control of Language

NCT03124173

Healthy

COMPLETED NA

The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study

NCT03588572

Subcortical Aphasia Ischemic Stroke

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

AVM - Cerebral Arteriovenous Malformation Language

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Geschwind's area BAVMs

Surgical removal of the BAVMs

Intervention Type PROCEDURE

Resection the BAVM nidus by microsurgery.

Healthy controls

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Surgical removal of the BAVMs

Resection the BAVM nidus by microsurgery.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Signed the informed consent form;
2. The dominant hand is the right hand (evaluated by the Edinburgh hand scale);
3. BAVM located in the left inferior parietal lobe
4. No history of rupture and bleeding and neurosurgical treatment

Exclusion Criteria

1. There are implants in the body (cardiac pacemaker, artificial femoral head, etc.);
2. The dominant hand is unclear;
3. Illiterate or other patients who can not cooperate well with cognitive function tests;
4. The history of bleeding in BAVM patients within one month;
5. History of neurosurgical treatment.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes