Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury

NCT ID: NCT04223726

Last Updated: 2024-04-25

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 210 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-08-22
• Study Completion Date: 2025-12-31

Brief Summary

CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.

Detailed Description

Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and mortality as well as impaired quality of life. Participants of this study all have severe CKD, defined as estimated glomerular filtration rate < 30 ml/min per 1.73 m^2. Stress ergometry, echocardiography, ultrasound assessment of arterial intima-media thickness, lateral lumbar radiograph, ECG, laboratory tests and quality of life assessment were performed at the baseline of the study and will be repeated during follow-up. Atrial fibrillation and other cardiac arrhythmias as well as pulse wave velocity measurements will be explored. Diet diaries are gathered and analysed. The aim of the study is to identify factors associated with cardiovascular disease, quality of life and mortality in this cohort.

Conditions

Kidney Diseases; Cardiovascular Diseases

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• estimated glomerular filtration rate < 30 ml/min per 1.73 m^2

Exclusion Criteria

• age under 18 years
• inability to give informed consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Turku University Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Kaj Metsärinne, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Turku University Hospital Kidney Center

Mikko J Järvisalo, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Turku University Hospital Intensive Care Unit

Locations

Turku University Hospital

Turku, , Finland

Countries

Finland

References

Lankinen R, Hakamaki M, Metsarinne K, Koivuviita N, Parkka JP, Saarenhovi M, Hellman T, Jarvisalo MJ. Association of maximal stress ergometry performance with troponin T and abdominal aortic calcification score in advanced chronic kidney disease. BMC Nephrol. 2021 Feb 4;22(1):50. doi: 10.1186/s12882-021-02251-y.

Reference Type: DERIVED

PMID: 33541279 (View on PubMed)

Other Identifiers

T41/2013

Identifier Type: -

Identifier Source: org_study_id