Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human
NCT ID: NCT02745444
Last Updated: 2021-09-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2015-04-30
2020-05-31
Brief Summary
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The protective effect of the low-calorie diet and also of the protein-restriction in donor on transplant qualities and functions in receptor will also be investigated.
Analysis of transcriptome, lipidome, metabolome, epigenome, proteome und phosphoproteome through tissue samples as well as blood samples for comparison of low-calorie diet, protein-restriction and no-diet groups.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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low-calorie formula diet
Donor taking low-calorie formula diet, 50% of basal energy rate, individually calculated with Mifflin-St. Jeor formula.
low-calorie formula diet
no diet
Donor ingesting food as usual.
No interventions assigned to this group
protein-restricted diet
Donor taking protein-restricted diet according to diet plans of clinical dietetics of University Hospital of Cologne, with unchanged calorie supply, individually calculated with Mifflin-St. Jeor formula.
protein-restricted diet
Normal protein supply
Donor taking same dishes as protein-restricted diet group but with customary protein levels, with unchanged calorie supply.
No interventions assigned to this group
Interventions
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low-calorie formula diet
protein-restricted diet
Eligibility Criteria
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Inclusion Criteria
* Competent patients
* Planned living kidney transplantation
* Provision of informed consent
* BMI ≥ 18,5 kg/m²
Exclusion Criteria
18 Years
ALL
No
Sponsors
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University of Cologne
OTHER
Responsible Party
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Volker Burst
MD
Principal Investigators
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Volker Burst, MD
Role: PRINCIPAL_INVESTIGATOR
Principal Investigator
Locations
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University Hospital of Cologne
Cologne, , Germany
Countries
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Other Identifiers
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CR_LSP
Identifier Type: -
Identifier Source: org_study_id
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