Acute Kidney Injury After Cardiac Arrest

NCT ID: NCT06544538

Last Updated: 2024-08-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

82 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-01

Study Completion Date

2022-12-31

Brief Summary

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The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.

For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.

Detailed Description

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This retrospective study was performed on patients hospitalized in intensive care units after cardiac arrest between 2013 and 2022. Patients who met the inclusion criteria were included in the study. Urea, creatinine values, and whether AKI was diagnosed or not were obtained from the data registry system. Statistical evaluation was performed using univariate binary logistic regression analysis.

Demographic data, location of cardiac arrest (in-hospital, out-of-hospital), and duration of CPR were recorded. In addition, the causes of cardiac arrest, HR/MAP (heart rate/average arterial pressure) ratio, and whether VSP (vasopressor) or INO (inotropic) medication was needed were recorded.

Conditions

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Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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AKI Group

AKI 1-3 in the first 48 hours after cardiac arrest according to KDIGO 2012 criteria

No interventions assigned to this group

Non-AKI Group

Those who did not develop AKI in the first 48 hours after cardiac arrest according to KDIGO 2012 criteria

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* adult patients with spontaneous circulation after cardiac arrest and admitted to the intensive care unit

Exclusion Criteria

* Deaths in the first 48 hours
* Missing data
* End stage CKD or first day hemadsorption
* CPR time \<3 min
* Unwitnessed cardiac arrest
* Terminal malignancy

* 90 years old
* Having a pace marker
* Massive bleeding
* ECMO application
* First day diyabetes insipitus
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bakirkoy Dr. Sadi Konuk Research and Training Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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MURAT ASLAN, Dr

Role: PRINCIPAL_INVESTIGATOR

Istanbul Bakırköy Dr Sadi Konuk Training and Research Hospital

Locations

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Bakırköy Dr. Sadi Konuk Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Nolan JP, Sandroni C, Bottiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021 Apr;47(4):369-421. doi: 10.1007/s00134-021-06368-4. Epub 2021 Mar 25.

Reference Type BACKGROUND
PMID: 33765189 (View on PubMed)

Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Ischemia/Reperfusion. Compr Physiol. 2016 Dec 6;7(1):113-170. doi: 10.1002/cphy.c160006.

Reference Type BACKGROUND
PMID: 28135002 (View on PubMed)

Lemiale V, Dumas F, Mongardon N, Giovanetti O, Charpentier J, Chiche JD, Carli P, Mira JP, Nolan J, Cariou A. Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort. Intensive Care Med. 2013 Nov;39(11):1972-80. doi: 10.1007/s00134-013-3043-4. Epub 2013 Aug 14.

Reference Type BACKGROUND
PMID: 23942856 (View on PubMed)

Adler C, Reuter H, Seck C, Hellmich M, Zobel C. Fluid therapy and acute kidney injury in cardiogenic shock after cardiac arrest. Resuscitation. 2013 Feb;84(2):194-9. doi: 10.1016/j.resuscitation.2012.06.013. Epub 2012 Jun 30.

Reference Type BACKGROUND
PMID: 22750662 (View on PubMed)

Patyna S, Riekert K, Buettner S, Wagner A, Volk J, Weiler H, Erath-Honold JW, Geiger H, Fichtlscherer S, Honold J. Acute kidney injury after in-hospital cardiac arrest in a predominant internal medicine and cardiology patient population: incidence, risk factors, and impact on survival. Ren Fail. 2021 Dec;43(1):1163-1169. doi: 10.1080/0886022X.2021.1956538.

Reference Type BACKGROUND
PMID: 34315321 (View on PubMed)

Other Identifiers

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2023/250

Identifier Type: -

Identifier Source: org_study_id

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