The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin

NCT ID: NCT05303441

Last Updated: 2022-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

172 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-07

Study Completion Date

2023-02-01

Brief Summary

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Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome

Detailed Description

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Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome and the final diagnosis of AMI will be adjudicated by 2 independent cardiologists.Serial troponin measurements and eGFR values will be proportioned. These values the will be evaluated and compared for patients with acute coronary syndrome(culprit lesion on conventional coronary angiography) and non-ACS ones . With these data we aim to facilitate the diagnosis of acute coronary syndrome,increase the specificity and sensitivity of cardiac troponins for the diagnosis of acute coronary syndrome of patients with chronic kidney disease, increase the utility of high sensitive troponins for patients with chronic kidney disease. Again, with these data, it is aimed to reduce the number of false negative and false positive diagnosis of acute coronary syndrome .

Conditions

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Acute Coronary Syndrome Chronic Kidney Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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patients with acute coronary syndrome

patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels compatible with ACS

percutaneous coronary intervention

Intervention Type PROCEDURE

conventional coronary angiography

patients without acute coronary syndrome

patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels NONcompatible with ACS

No interventions assigned to this group

Interventions

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percutaneous coronary intervention

conventional coronary angiography

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Age over 18,
2. chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -

Exclusion Criteria

1. STEMI,
2. age less than 18,
3. missing data,
4. patients referred to or accepted from another medical facility
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ankara Diskapi Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Bedriye Muge Sonmez

associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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bedriye müge sönmez, assoc. prof.

Role: STUDY_DIRECTOR

research

Locations

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Diskapi Research and Training Hospital

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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bedriye müge sönmez, assoc. prof.

Role: CONTACT

+903125962470

elif hamzaçebioğlu, resident

Role: CONTACT

+903125962469

Facility Contacts

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bedriye müge sönmez, assoc. prof

Role: primary

+905055823208

References

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Hamzacebioglu E, Sonmez BM, Akcay G, Tulmac M, Kayisoglu S, Hatil SI, Gungor EB. Valency of cystatin C and creatinine on troponin values in chronic kidney disease patients with chest pain in emergency department. Am J Emerg Med. 2025 Mar;89:95-102. doi: 10.1016/j.ajem.2024.12.020. Epub 2024 Dec 13.

Reference Type DERIVED
PMID: 39705855 (View on PubMed)

Other Identifiers

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AnkaraDiskapiTRH

Identifier Type: -

Identifier Source: org_study_id

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