Ocular Microvascular Changes in Patients With Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

76 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-02

Study Completion Date

2019-08-31

Brief Summary

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This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic patients

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Detailed Description

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Conjunctival imaging, using IDF video microscope, and retinal imaging, using portable digital fundus camera, as well as systemic hemodynamic measurements, were performed in septic patients at three time points: at baseline, 6 hours and 24 hours. Baseline conjunctival and retinal microcirculatory parameters were compared with healthy controls.

Conditions

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Sepsis Retinal Microcirculation Disorder Conjunctiva; Disorder

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Incident dark field videomicroscope from Braedius

It allows to look at conjunctival microcirculation

Intervention Type DEVICE

Fundus camera from Optomed

It allows to monitor retinal microvasculature

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* adult patients with sepsis or septic shock within the first 24 hours after ICU admission

Exclusion Criteria

* psychiatric disorders, brain diseases, chronic alcoholism, autoimmune rheumatic diseases
* ophthalmological diseases, such as glaucoma, age-related macular degeneration, diabetic retinopathy and cataract

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes