Functional Decline and QoL in People Aging with HIV in Asia

NCT ID: NCT04212884

Last Updated: 2025-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-01

Study Completion Date

2025-01-31

Brief Summary

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This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people living with HIV (PLWH) in Asia.

Detailed Description

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This research project is expected to have the following clinical impact

1. To understand the impact of impaired functional status in PLWH in Asia would be important to determine the long-term health burden needs in this aging population in this part of the world.
2. The identification of risk factors associated with impaired functional status would be important to guide clinical decisions in patient management, such as the choice of anti-retroviral regimen, and screening of and early intervention for modifiable risk factors. These are of paramount importance in the promotion of healthy aging in this population.
3. This proposed cross-sectional study lays the foundation for the establishment of a longitudinal cohort for long-term follow up of people aging with HIV in Asia, with the objectives of evaluating the long-term impact of aging on clinical outcomes and functional status in PLWH in this region.

Conditions

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Frailty Disability Physical HIV/AIDS

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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PLWH

PLWH followed up at the five participating HIV centers

No interventions assigned to this group

HIV-uninfected individuals

Age and sex-matched HIV-uninfected individuals

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* HIV antibody positive
* Age 35 years or above
* Asian ethnicity, including but not limited to Chinese, Malay and Indian

Exclusion Criteria

* Inability or refusal to consent
* Active infections requiring in-hospital treatment
Minimum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Malaya

OTHER

Sponsor Role collaborator

National Taiwan University

OTHER

Sponsor Role collaborator

Chongqing Public Health Medical Center

OTHER

Sponsor Role collaborator

Tan Tock Seng Hospital

OTHER

Sponsor Role collaborator

Chinese University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Shui-Shan Lee, MD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Grace LUI

Role: PRINCIPAL_INVESTIGATOR

Chinese University of Hong Kong

Locations

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Prince of Wales Hospital

Hong Kong, , Hong Kong

Site Status

Prince of Wales Hospital

Shatin, , Hong Kong

Site Status

Countries

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Hong Kong

Other Identifiers

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Geri_HIV_protocol_v4_26Nov2019

Identifier Type: -

Identifier Source: org_study_id

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