Factors Associated With Advanced HIV and Poor Nutrition Among People Living With HIV
NCT ID: NCT06852430
Last Updated: 2025-02-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
100 participants
OBSERVATIONAL
2025-02-22
2027-02-01
Brief Summary
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1. To determine the frequency of advanced HIV among PLWH in Assiut University Hospital.
2. To assess the nutritional patterns and frequency of poor nutrition among PLWH.
3. To evaluate factors associated with advanced HIV disease and poor nutrition among PLWH.
Detailed Description
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The WHO defines advanced HIV disease as having CD4+ T-cell count \<200 cell/mm3 or having an acquired immune deficiency syndrome (AIDS)-related infection (stage 3 or 4 of HIV infection) regardless of the CD4+ T-cell count (1).
The WHO reported, in 2022, that 630,000 people living with HIV (PLWH) died from AIDS-related diseases worldwide (which is 51% fewer than those in 2010) (2, 3, 6). In Egypt, the AIDS-related deaths increased from \<100 PLWH in 1990 to \<1000 PLWH in 2021 (5).
PLWH are usually malnourished due to opportunistic infections, poor food intake, changes in metabolic activity or chronic illnesses. Malnutrition leads to more impairment of the immune system and further disease progression (7).
According to 2023 Global Hunger index, Egypt is at a moderate level of food insecurity, ranking 57 out of 125 countries. 14.4% of the Egyptian population are food insecure (8).
In Egypt, there is lack of data about the frequency of advanced HIV disease and the nutritional status among PLWH and associated factors. Monitoring these factors could help in early treatment of HIV infection, prevention of further virus transmission and enhancement of the nutritional pattern among PLWH.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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People living with Advanced HIV disease
Factors associated with advanced HIV disease
No interventions assigned to this group
People with Early HIV disease
Factors associated with early HIV disease
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Salma Hussein Badry
Doctor
Principal Investigators
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Haidi KaramAllah Ramadan, Assisstant professor
Role: STUDY_DIRECTOR
Assiut University
Ehab Fawzy Abdou, Professor
Role: PRINCIPAL_INVESTIGATOR
Assiut University
Central Contacts
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References
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Boutros S, Skordis J. HIV/AIDS surveillance in Egypt: current status and future challenges. East Mediterr Health J. 2010 Mar;16(3):251-8.
Rezazadeh L, Ostadrahimi A, Tutunchi H, Naemi Kermanshahi M, Pourmoradian S. Nutrition interventions to address nutritional problems in HIV-positive patients: translating knowledge into practice. J Health Popul Nutr. 2023 Sep 8;42(1):94. doi: 10.1186/s41043-023-00440-z.
Ghazy RM, Al Awaidy S, Taha SHN. Trends of HIV indicators in Egypt from 1990 to 2021: time-series analysis and forecast toward UNAIDS 90-90-90 targets. BMC Public Health. 2023 Apr 1;23(1):625. doi: 10.1186/s12889-023-15490-5.
Study Documents
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Document Type: Study Protocol
View DocumentRelated Links
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WHO page about HIV, available at: https://www.who.int/news-room/fact-sheets/detail/hiv-aids?gad\_source=1\&gclid=Cj0KCQjwvb-zBhCmARIsAAfUI2sL\_nGP-V-oca55dZe0OroljeQgljfFO5\_s1FhbC6xFMxF\_mWBCr
WHO 2022, available at: https://www.who.int/news-room/fact-sheets/detail/hiv-aids?gad\_source=1\&gclid=Cj0KCQjwvb-zBhCmARIsAAfUI2sL\_nGP-V-oca55dZe0OroljeQgljfFO5\_s1FhbC6xFMxF\_mWBCr
Other Identifiers
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Advanced HIV, poor nutrition
Identifier Type: -
Identifier Source: org_study_id