Additional Benefit of Thoracic Impedance Monitoring (TIM) for Propofol-sedation Monitoring During PEG Placement

NCT ID: NCT04202029

Last Updated: 2023-07-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

173 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-04

Study Completion Date

2021-08-24

Brief Summary

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The present study is a randomized, prospective, single-blinded study. A total of 172 patients presenting for percoutaneous endoscopic gastrostomy (PEG) under sedation will be included according to the statistical sample size calculation. Patients will be randomized to either group 1- standard monitoring (pulseoxymetry and non-invasive blood preassure monitoring) or group 2- standard monitoring and thoracic impedance measurement during Propofol-based sedation for PEG. Episodes of Hypoxia are documented and compared in both groups.

Statistical analysis will be done in cooperation with the statistical biomedical institute oft he university hospital in Frankfurt.

Detailed Description

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Conditions

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Percutaneous Endoscopic Gastrostomy (PEG)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The participants will be randomely assigend by a computer based algorithm to either the standard monitoring group as defined by the German S3 guidline "Sedierung in der gastrointestinalen Endoskopie" containing pulsoxymetry and non-invasive blood preassure monitoring versus the standard and additionally the thoracic impedance monitoring using an extra ECG
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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pulseoxymetry arm

pulseoxymetry arm: standard monitoring: pulseoxymetry and non-invasive blood preassure monitoring

Group Type OTHER

pulseoxymetry

Intervention Type DEVICE

Pulseoxymetry is meassuring the heart rate and the oxygen saturation in the arterial blood

non-invasive blood preassure monitoring

Intervention Type DEVICE

Non-invasive blood preassure is a method using a blood preassure cuff to identify the blood preassure.

thoracic impedance monitoring arm

thoracic impedance monitoring arm: standard monitoring and additionally thoracic impedance measurement)

Group Type EXPERIMENTAL

thoracic impedance monitoring

Intervention Type DEVICE

Thoracic impedance measurement identifies the respiratory frequence using the changes of impedance during inspiration and expiration via an ECG.

pulseoxymetry

Intervention Type DEVICE

Pulseoxymetry is meassuring the heart rate and the oxygen saturation in the arterial blood

non-invasive blood preassure monitoring

Intervention Type DEVICE

Non-invasive blood preassure is a method using a blood preassure cuff to identify the blood preassure.

Interventions

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thoracic impedance monitoring

Thoracic impedance measurement identifies the respiratory frequence using the changes of impedance during inspiration and expiration via an ECG.

Intervention Type DEVICE

pulseoxymetry

Pulseoxymetry is meassuring the heart rate and the oxygen saturation in the arterial blood

Intervention Type DEVICE

non-invasive blood preassure monitoring

Non-invasive blood preassure is a method using a blood preassure cuff to identify the blood preassure.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* \> /= 18 years
* given consent
* planned PEG

Exclusion Criteria

* ASA \>/= 4
* no given consent
* pregnant/laction
* contraindication against PEG
* contraindication against propofol-sedatation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Georg Dultz

OTHER

Sponsor Role lead

Responsible Party

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Georg Dultz

Clinical Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Klinikum der J. W. Goethe-Universität

Frankfurt am Main, , Germany

Site Status

Countries

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Germany

References

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Jafari A, Weismuller TJ, Tonguc T, Kalff JC, Manekeller S. [Complications after Percutaneous Endoscopic Gastrostomy Tube Placement - A Retrospective Analysis]. Zentralbl Chir. 2016 Aug;141(4):442-5. doi: 10.1055/s-0035-1557765. Epub 2015 Aug 10. German.

Reference Type BACKGROUND
PMID: 26258619 (View on PubMed)

Riphaus A, Rabofski M, Wehrmann T. Endoscopic sedation and monitoring practice in Germany: results from the first nationwide survey. Z Gastroenterol. 2010 Mar;48(3):392-7. doi: 10.1055/s-0028-1109765. Epub 2010 Feb 5.

Reference Type BACKGROUND
PMID: 20140841 (View on PubMed)

Riphaus A, Geist F, Wehrmann T. Endoscopic sedation and monitoring practice in Germany: re-evaluation from the first nationwide survey 3 years after the implementation of an evidence and consent based national guideline. Z Gastroenterol. 2013 Sep;51(9):1082-8. doi: 10.1055/s-0033-1335104. Epub 2013 Sep 10.

Reference Type BACKGROUND
PMID: 24022202 (View on PubMed)

Lin OS. Sedation for routine gastrointestinal endoscopic procedures: a review on efficacy, safety, efficiency, cost and satisfaction. Intest Res. 2017 Oct;15(4):456-466. doi: 10.5217/ir.2017.15.4.456. Epub 2017 Oct 23.

Reference Type BACKGROUND
PMID: 29142513 (View on PubMed)

Dumonceau JM, Riphaus A, Aparicio JR, Beilenhoff U, Knape JT, Ortmann M, Paspatis G, Ponsioen CY, Racz I, Schreiber F, Vilmann P, Wehrmann T, Wientjes C, Walder B; NAAP Task Force Members. European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of Anaesthesiology Guideline: Non-anaesthesiologist administration of propofol for GI endoscopy. Eur J Anaesthesiol. 2010 Dec;27(12):1016-30. doi: 10.1097/EJA.0b013e32834136bf.

Reference Type BACKGROUND
PMID: 21068575 (View on PubMed)

Riphaus A, Wehrmann T, Hausmann J, Weber B, von Delius S, Jung M, Tonner P, Arnold J, Behrens A, Beilenhoff U, Bitter H, Domagk D, In der Smitten S, Kallinowski B, Meining A, Schaible A, Schilling D, Seifert H, Wappler F, Kopp I; German Society of General and Visceral Surgery; German Crohn's disease / ulcerative colitis Association e. V; German Society of Anaesthesiology and Intensive Care Medicine e. V. (DGAI); Gesellschaft Politics and Law in Health Care (GPRG). [S3-guidelines "sedation in gastrointestinal endoscopy" 2014 (AWMF register no. 021/014)]. Z Gastroenterol. 2015 Aug;53(8):802-42. doi: 10.1055/s-0035-1553458. Epub 2015 Aug 18. No abstract available. German.

Reference Type BACKGROUND
PMID: 26284330 (View on PubMed)

Absolom M, Roberts R, Bahlmann UB, Hall JE, Armstrong T, Turley A. The use of impedance respirometry to confirm tracheal intubation in children. Anaesthesia. 2006 Dec;61(12):1145-8. doi: 10.1111/j.1365-2044.2006.04838.x.

Reference Type BACKGROUND
PMID: 17090233 (View on PubMed)

Frasca D, Geraud L, Charriere JM, Debaene B, Mimoz O. Comparison of acoustic and impedance methods with mask capnometry to assess respiration rate in obese patients recovering from general anaesthesia. Anaesthesia. 2015 Jan;70(1):26-31. doi: 10.1111/anae.12799. Epub 2014 Jul 10.

Reference Type BACKGROUND
PMID: 25040754 (View on PubMed)

Other Identifiers

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FRA-UNI-TIM-PEG-TRIAL-2019

Identifier Type: -

Identifier Source: org_study_id

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