Ethnic Differences in Iron Absorption (FeGenes)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

515 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-01

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to; 1) investigate population differences in iron absorption between East Asians and Northern Europeans; 2) assess population differences in hormonal and biochemical determinants of Fe absorption between East Asians and Northern Europeans; and 3) to investigate genetic contributions to Fe absorption, Fe status and Fe regulatory hormones between East Asians and Northern Europeans.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Genetic Variants and Iron Absorption

NCT02197624

Iron Absorption

COMPLETED

Verification of Correlation Between Genetic Testing of Nutritional Metabolism and Clinical Biochemical Indicators

NCT03651934

Pregnant Women

UNKNOWN NA

Pharmacogenetics Study in Taiwan's Ethnic Groups

NCT00459251

Healthy

COMPLETED

Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing

NCT01516125

Healthy

COMPLETED

GWAS Identified Susceptibility Loci for Glucocorticoid-induced FHN in the Chinese Population

NCT02365077

Femur Head Necrosis Adverse Effect of Glucocorticoids and Synthetic Analogues

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Detailed description:

This study will utilize a multidisciplinary approach to identify genetic variation in genes that control iron utilization in order to shed light on the genetic basis of population differences in iron status and disease susceptibility with a long-term goal of informing population-specific dietary iron intake recommendations to minimize the risk of chronic diseases. To evaluate iron utilization, we will employ an in vivo, functional approach using an oral stable iron isotope method. Each participant will have genetic ancestry and genotyping evaluated using the Illumina Global Diversity Array-8. Study participants (n=504, aged 18-50 y) will consume 57Fe (as ferrous sulfate) in the fasted state and will then ingest a standardized breakfast and lunch meal. Two weeks after iron dosing, a blood sample will be collected from each participant and the amount of 57Fe incorporated into red blood cells will be measured using magnetic sector thermal ionization mass spectrometry. This project will fundamentally advance our understanding of ethnic differences in nutrient metabolism and iron status. It will also provide information to assist with the long-term goal of reducing the public health burden of Fe-related diseases.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Anemia, Iron Deficiency Iron Overload

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy adults
* Age between 18- 50y
* Non-smoking
* Not taking vitamin or mineral supplements.
* Females: premenopausal and not pregnant or lactating
* No preexisting medical complications (such as eating disorders, hemoglobinopathies, malabsorption diseases, steroid use, substance abuse history, or taking medications known to influence iron homeostasis)
* Body mass index (BMI) between 18 - 30 kg/m2.

Exclusion Criteria

* BMI \<18 or \> 30 kg/m2,
* Age \<18 y or \> 50y,
* Not of Northern European or East Asian ancestry
* Smoking
* Pregnancy, lactating
* Have gastrointestinal disorders/malabsorption diseases/hemoglobinopathies/dietary restrictions/steroid use/ medication use of medications known to impact iron status, iron utilization or inflammatory status
* Take vitamin and mineral supplementations

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes