Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

198 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-15

Study Completion Date

2019-01-15

Brief Summary

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Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.

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Detailed Description

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Conditions

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Pain, Postoperative Thoracic Surgery, Video-Assisted Polymorphism, Single Nucleotide

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Postoperative Analgesic Failure

Genetic analysis

Intervention Type GENETIC

Collect 2ml intravenous blood from patients after anaesthesia.

Postoperative Analgesic Success

Genetic analysis

Intervention Type GENETIC

Collect 2ml intravenous blood from patients after anaesthesia.

Interventions

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Genetic analysis

Collect 2ml intravenous blood from patients after anaesthesia.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Age ≤ 70 and Age ≥18
* Selective operation lung section with video-assisted thoracic surgery (VATS)
* III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I
* Patients informed and agreed to join the study

Exclusion Criteria

* Abnormal function of liver and kidney
* Allergic- dependence history of alcohol, opioids and Local anesthetics
* No noncompliance
* Mental disease history，language communication disorder，cicatricial diathesis
* Underweight or overweight（BMI\<18 or \>30)
* Patients not suitable for clinical subjects for other reasons
* Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation.
* History of previous abnormal anaesthesia
* Women during pregnancy or lactation

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No