Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis

NCT ID: NCT04174807

Last Updated: 2021-08-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-01

Study Completion Date

2022-05-01

Brief Summary

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Gastroschisis is a rare congenital malformation consisting in a right para-umbilical defect of the abdominal wall leading to an evisceration of the abdominal content. About 25% of the cases are associated with intestinal malformation, leading to an increase in peri-natal morbidity and mortality. No prospective study has been able to definitely describe predictive factors for complicated gastroschisis on prenatal ultrasound examinations.

The aim of the current study is to prospectively look for US prenatal features predictive of complicated gastroschisis, on a national multicentric cohort.

Patients will be included during the 22 weeks of amenorrhea (WA) ultrasound examination, and pre- and postnatal clinical data will be recorded up to the 6th months of the child.

Data will then be analysed and compared in the groups of simple or complicated gastroschisis, in order to define pre-natal prognostic factors, to correlate them with specific prognosis, and to might better determine specific strategies for better care of these patients.

Detailed Description

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Conditions

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Gastroschisis Intestinal Occlusion

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cohort

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Every volunteer pregnant woman, in whom an antenatal ultrasound diagnosis of gastroschisis has been carried, before the end of 22 weeks of amenorrhea.

Exclusion Criteria

Lack of informed consent or refusal of the person to participate in study
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Françoise SCHMITT, Dr

Role: PRINCIPAL_INVESTIGATOR

UH Angers

Locations

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University Hospital of Amiens

Amiens, , France

Site Status NOT_YET_RECRUITING

University Hospital of Angers

Angers, , France

Site Status RECRUITING

University Hospital of Besançon

Besançon, , France

Site Status RECRUITING

University Hospital of Bordeaux

Bordeaux, , France

Site Status RECRUITING

University Hospital of Brest

Brest, , France

Site Status RECRUITING

University Hospital of Caen

Caen, , France

Site Status RECRUITING

University Hospital of Bicêtre

Clamart, , France

Site Status RECRUITING

University Hospital of Clermont-Ferrand

Clermont-Ferrand, , France

Site Status RECRUITING

University Hospital of Dijon

Dijon, , France

Site Status NOT_YET_RECRUITING

University Hospital of Grenoble

Grenoble, , France

Site Status RECRUITING

University Hospital of Le Havre

Le Havre, , France

Site Status NOT_YET_RECRUITING

University Hospital of Le Mans

Le Mans, , France

Site Status RECRUITING

University Hospital of Lens

Lens, , France

Site Status RECRUITING

University Hospital of Lille

Lille, , France

Site Status RECRUITING

University Hospital of Limoges

Limoges, , France

Site Status RECRUITING

University Hospital of Lyon

Lyon, , France

Site Status NOT_YET_RECRUITING

University Hospital of Marseille

Marseille, , France

Site Status NOT_YET_RECRUITING

University Hospital of Montpellier

Montpellier, , France

Site Status RECRUITING

University Hospital of Nancy

Nancy, , France

Site Status RECRUITING

University Hospital of Nantes

Nantes, , France

Site Status RECRUITING

University Hospital of Nice

Nice, , France

Site Status NOT_YET_RECRUITING

University Hospital of Nîmes

Nîmes, , France

Site Status RECRUITING

University Hospital of Orléans

Orléans, , France

Site Status RECRUITING

University Hospital of Necker

Paris, , France

Site Status RECRUITING

University Hospital of Robert Debré

Paris, , France

Site Status RECRUITING

University Hospital of Trousseau

Paris, , France

Site Status RECRUITING

University Hospital of Poitiers

Poitiers, , France

Site Status RECRUITING

University Hospital of René Dubos

Pontoise, , France

Site Status RECRUITING

University Hospital of Reims

Reims, , France

Site Status RECRUITING

University Hospital of Rennes

Rennes, , France

Site Status RECRUITING

University Hospital of Rouen

Rouen, , France

Site Status NOT_YET_RECRUITING

University Hospital of Saint-Etienne

Saint-Etienne, , France

Site Status RECRUITING

University Hospital of Strasbourg

Strasbourg, , France

Site Status RECRUITING

University Hospital of Toulouse

Toulouse, , France

Site Status RECRUITING

University Hospital of Tours

Tours, , France

Site Status RECRUITING

University Hospital of Fort de France

Fort-de-France, , Martinique

Site Status RECRUITING

Countries

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France Martinique

Central Contacts

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Magali FAUCHERE

Role: CONTACT

+33(0)2 41 35 63 24

References

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Geslin D, Clermidi P, Gatibelza ME, Boussion F, Saliou AH, Le Manac'h Dove G, Margaryan M, De Vries P, Sentilhes L, Levard G, Lardy H, Arnaud A, Leclair MD, Podevin G, Schmitt F. What prenatal ultrasound features are predictable of complex or vanishing gastroschisis? A retrospective study. Prenat Diagn. 2017 Feb;37(2):168-175. doi: 10.1002/pd.4984. Epub 2017 Jan 25.

Reference Type RESULT
PMID: 27981591 (View on PubMed)

Kassa AM, Lilja HE. Predictors of postnatal outcome in neonates with gastroschisis. J Pediatr Surg. 2011 Nov;46(11):2108-14. doi: 10.1016/j.jpedsurg.2011.07.012.

Reference Type RESULT
PMID: 22075340 (View on PubMed)

Kuleva M, Khen-Dunlop N, Dumez Y, Ville Y, Salomon LJ. Is complex gastroschisis predictable by prenatal ultrasound? BJOG. 2012 Jan;119(1):102-9. doi: 10.1111/j.1471-0528.2011.03183.x. Epub 2011 Oct 21.

Reference Type RESULT
PMID: 22017923 (View on PubMed)

Other Identifiers

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49-RC18-0155

Identifier Type: -

Identifier Source: org_study_id

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