Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
55 participants
OBSERVATIONAL
2019-12-02
2023-04-14
Brief Summary
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Detailed Description
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A new clinical routine has been implemented at the study centers: During the ICU stay screening with Beta-D-glucan and Galactomannan in blood/serum will be performed twice weekly and a respiratory sample will be retrieved for fungal culture and microscopy once weekly.
All results from collected samples will be available to the patient's attending physicians. Clinical and microbiological data will be collected, and the diagnosis of invasive aspergillosis will be made using predefined diagnostic criteria.
Objectives:
1. To determine the prevalence of influenza-related invasive pulmonary aspergillosis in Swedish intensive care units
2. To assess the clinical impact of and risk factors for influenza-related invasive pulmonary aspergillosis
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Admitted to the ICU
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Karolinska University Hospital
OTHER
Responsible Party
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Anders Krifors
Principal Investigator
Principal Investigators
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Anders Krifors, M.D.
Role: PRINCIPAL_INVESTIGATOR
Karolinska Institutet
Markus Castegren, M.D. Ph.D.
Role: STUDY_DIRECTOR
Karolinska Institutet
Ola Blennow, M.D. Ph.D.
Role: STUDY_CHAIR
Karolinska Institutet
Johan Petersson, M.D. A/Prof.
Role: STUDY_CHAIR
Karolinska Institutet
Locations
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ICU at Mälarsjukhuset
Eskilstuna, , Sweden
ICU at Helsingborgs lasarett
Helsingborg, , Sweden
ICU at Länssjukhuset Ryhov
Jönköping, , Sweden
ICU at Universitetssjukhuset
Linköping, , Sweden
ICU at Skånes universitetssjukhus
Lund, , Sweden
ICU at Skånes universitetssjukhus
Malmo, , Sweden
ICU at Universitetssjukhuset
Örebro, , Sweden
ICU at Danderyds sjukhus
Stockholm, , Sweden
ICU at Karolinska Universitetssjukhuset Huddinge
Stockholm, , Sweden
ICU at Karolinska Universitetssjukhuset Solna
Stockholm, , Sweden
ICU at Akademiska sjukhuset
Uppsala, , Sweden
ICU at Västmanlands sjukhus
Västerås, , Sweden
Countries
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References
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Krifors A, Blennow O, Pahlman LI, Gille-Johnson P, Janols H, Lipcsey M, Kallman J, Tham J, Stjarne Aspelund A, Ljungquist O, Hammarskjold F, Hallgren A, De Geer L, Lemberg M, Petersson J, Castegren M. Influenza-associated invasive aspergillosis in patients admitted to the intensive care unit in Sweden: a prospective multicentre cohort study. Infect Dis (Lond). 2024 Feb;56(2):110-115. doi: 10.1080/23744235.2023.2273381. Epub 2023 Dec 18.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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K 2019-9546
Identifier Type: -
Identifier Source: org_study_id
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