PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar Lavage Fluid for Monitoring Cases of Invasive Aspergillosis: What is Its Prognostic Value

NCT ID: NCT07313527

Last Updated: 2026-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-17

Study Completion Date

2026-02-28

Brief Summary

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Aspergillus fumigatus PCR is currently used in conjunction with serum galactomannan to support the diagnosis of invasive aspergillosis or for monitoring at-risk patients not receiving antifungal prophylaxis. A positive result and a high titer are thought to be associated with the advanced stage of the disease and the fungal load. However, there is limited data on this subject, and no study has primarily focused on the variation of PCR levels during treatment and its potential correlation with treatment efficacy.

Detailed Description

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Conditions

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Invasive Pulmonary Aspergillosis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients aged 18 years or older
* Positive Aspergillus fumigatus PCR on serum or bronchoalveolar lavage fluid at diagnosis, performed at the Strasbourg University Hospital between January 1, 2017, and December 31, 2024.

Exclusion Criteria

* No subsequent Aspergillus fumigatus PCR (\>24h)
* No diagnosis of probable or proven invasive aspergillosis (EORTC/MSGERC 2020 criteria)
* Effective antifungal treatment against Aspergillus initiated before the first PCR
* Death \<72h after starting antifungal treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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baptiste Hoellinger, MD

Role: CONTACT

33 3 69 55 05 45

Facility Contacts

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Baptiste Hoellinger, MD

Role: primary

33 3 69 55 05 45

Other Identifiers

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9615

Identifier Type: -

Identifier Source: org_study_id

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