How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages (Exosomes) From Fat Tissue in Lean and Obese Patients

NCT ID: NCT04167722

Last Updated: 2021-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-01

Study Completion Date

2024-10-01

Brief Summary

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The investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.

Detailed Description

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Both obesity and prostate cancer are major health problems in the UK, affecting 1 in 3 and 1 in 8 men respectively. Moreover, obesity increases the risk of developing aggressive disease and the risk of prostate cancer spreading. How this happens is not known. The investigators want to understand how fat cells communicate with prostate cancer cells. Investigators will be collecting prostate and fat tissue from radical prostatectomy participants for culture, in particular to look at exosome communication.

Conditions

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Prostate Cancer Obesity

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Obese patients

BMI \> 25

Robotic Radical Prostatectomy

Intervention Type PROCEDURE

Routine NHS Radical Prostatectomy

Lean patients

BMI \< or = 25

Robotic Radical Prostatectomy

Intervention Type PROCEDURE

Routine NHS Radical Prostatectomy

Interventions

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Robotic Radical Prostatectomy

Routine NHS Radical Prostatectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* All men undergoing radical prostatectomy at Charing Cross Hospital

Exclusion Criteria

* Patients unable to consent
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Imperial College Healthcare NHS Trust

OTHER

Sponsor Role collaborator

Experimental Cancer Medicine Centres

OTHER

Sponsor Role collaborator

Imperial College London

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Charlotte Bevan, PhD

Role: PRINCIPAL_INVESTIGATOR

Imperial College London

Mathias Winkler, FRCS

Role: PRINCIPAL_INVESTIGATOR

Imperial College Healthcare NHS Trust

Locations

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Charing Cross Hospital, Imperial College Healthcare NHS Trust

London, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Joseph Tam, MBBCh

Role: CONTACT

+442075942135

Becky Ward

Role: CONTACT

+442075949459

Facility Contacts

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Mathias Winkler, FRCS

Role: primary

+44203311234

Joseph Tam, MBBCh

Role: backup

+442075942135

Other Identifiers

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19HH5065

Identifier Type: -

Identifier Source: org_study_id

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