Identifying and Genotyping Homozygous Familial Hypercholesterolemia (HoFH) Patients

NCT ID: NCT04148001

Last Updated: 2021-02-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 4 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-12-04
• Study Completion Date: 2020-04-08

Brief Summary

This study is designed to help identify patients with HoFH due to mutations in the LDLR as confirmed by genotyping.

Detailed Description

This is a non-interventional study; no investigational product is administered in this study. Information collected in this study may be used to identify potential participants for clinical gene therapy trials in HoFH.

The investigator will discuss the study with participants who have a clinical presentation consistent with HoFH and where possible, the treating physician, in order to assess their interest to participate. After informed consent has been obtained, participants will be asked to provide a blood sample (up to 40 mL) for genotyping to confirm genetic diagnosis of HoFH due to mutations in LDLR, a lipid panel and anti-AAV8 NAb titer. Participants and, whenever possible, their treating physician will complete a medical history questionnaire and provide supporting documentation. The informed consent form (ICF) and data collection methods may vary depending whether the informed consent is obtained remotely or at a participating study site.

Information collected will include the following:

• patient demographics (age, sex, weight)
• medical history
• previous genotype results (if available)
• results of most recent lipid panel(s)
• use of lipid lowering therapies, including failure to respond
• assessment of presence of liver disease, including history of hepatitis B and C, human immunodeficiency virus (HIV), cirrhosis, and alcohol use

Once this information is received by the investigator and Sponsor, a preliminary assessment of confirmation of a diagnosis of HoFH will be performed. Participants and/or their treating physician will be informed of the results of the genetic testing. All participants will be provided an opportunity to speak with a genetic counselor upon receiving the results of the genetic testing.

Data collected in this study may be used to identify potential candidates for separate clinical trial(s) using gene therapy.

Conditions

Homozygous Familial Hypercholesterolemia (HoFH)

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Males and females ≥ 18 years of age

2. Clinical presentation consistent with HoFH

Exclusion Criteria

1. History of cirrhosis based on documented histological evaluation or noninvasive imaging

2. Documented diagnosis of liver diseases

3. History of immunodeficiency diseases, including a positive HIV test result

4. Previous organ transplantation

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

REGENXBIO Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Excel Medical Clinical Trials, LLC

Boca Raton, Florida, United States

Countries

United States

Other Identifiers

RGX-501-9101

Identifier Type: -

Identifier Source: org_study_id