Tissue Microarray of Hematological Malignancies

NCT ID: NCT04142372

Last Updated: 2024-04-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-10

Study Completion Date

2026-12-31

Brief Summary

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The aim of the study is to create new tools for improving management of patients with hematological malignancies by combining extensive clinical data from patients newly diagnosed with hematological malignancies and innovative laboratory analyses made on available tissue samples in regional biobanks from these patients.

Detailed Description

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Firstly, clinical information is collected on all hematological malignancies diagnosed in our hospital district area retrospectively between the years 2000 and 2019. Clinical outcomes, laboratory results, clinically relevant diagnoses, characteristics defining clinical stage and established prognostic parameters are gathered.

Simultaneously a tissue microarray (TMA) of diagnostic samples is compiled using representative annotated tissue areas. This TMA is used in combination with additional control material to identify prognostic and predictive biomarkers.

A combined microarray dataset of hematological malignancies (Hemap) is utilized to point out genes of possible drug targets, disease specific markers, prognostic markers, or predictive markers.

The clinical datasets and Hemap dataset is ultimately utilized to gain knowledge, new tools for prognostication and diagnostics, and targets for treatment. Artificial intelligence -assisted differential diagnostics will be tested.

Conditions

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Hematological Malignancies

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* hematological malignancy/neoplasm

Exclusion Criteria

* Non-sufficient data available
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tampere University

OTHER

Sponsor Role collaborator

University of Eastern Finland

OTHER

Sponsor Role collaborator

Fimlab Oy

UNKNOWN

Sponsor Role collaborator

Helsinki University Central Hospital

OTHER

Sponsor Role collaborator

Tampere University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Matti Vänskä

Principal Investigator, MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Artturi Mäkinen, MD

Role: PRINCIPAL_INVESTIGATOR

Tampere University

Olli Lohi, MD, PhD

Role: STUDY_CHAIR

Tampere University

Merja Heinäniemi, PhD

Role: STUDY_CHAIR

University of Eastern Finland

Matti Vänskä, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Tiina Lyly-Yrjänäinen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Locations

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Tampere Univerisity Hospital

Tampere, , Finland

Site Status

Countries

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Finland

Other Identifiers

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R19060B

Identifier Type: -

Identifier Source: org_study_id

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