Micro Assays for HemATology Malignancies Antibody Treatment

NCT ID: NCT07018310

Last Updated: 2025-11-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 166 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-01-31
• Study Completion Date: 2029-01-31

Brief Summary

Hematological malignancy is a disease of the blood. In some cases, this pathology requires therapeutic management, which is not necessarily the case for you. Nevertheless, to improve the management of patients who need it, we are conducting research to assess the state of your immune system. Indeed, the role of the immune system is not limited to controlling infections, but is also important in controlling the proliferation of cancer cells, in hematology as in other types of cancer. Your immune system can play a spontaneous anti-tumor control role, but some so-called "immunotherapy" treatments aim to destroy cancer cells by stimulating the immune system, restoring its capabilities, and directing the immune response against tumor cells. For this immunotherapy treatment to be effective, since it uses your own immune cells (in most cases), these cells must be in a state to respond and be able to destroy the tumor. It is this ability to activate immune cells that is tested in this research protocol, using a simple test that could in future be used in routine clinical practice. But to understand why these immune cells don't work, we will also have to carry out genetic tests to analyze the various molecules that could interfere with the immune response, and try to inhibit the molecules that prevent the immune response.

Conditions

Hematological Malignancy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

blood sampling

blood sampling in patients with hematological malignancies

Group Type: EXPERIMENTAL

blood sampling

Intervention Type: OTHER

Additional blood sampling as part of routine care

Interventions

blood sampling

Additional blood sampling as part of routine care

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Male or Female over 18 years of age
• Patient with a hematological malignancy likely to benefit from immunotherapy (in any form; at the discretion of the referring physician)
• Before the start of 1st-line treatment, successive lines or before autograft (chemotherapy-free for at least 4 weeks in these cases).
• Patient has received information about the study and has not expressed opposition.
• Patient who is a beneficiary or entitled beneficiary of a social security scheme

Exclusion Criteria

• Person in a period of exclusion from another research protocol at the time the non-opposition is signed.
• Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code, i.e. :

• Persons deprived of their liberty by judicial or administrative decision
• Persons subject to psychiatric monitoring under articles L3112-1 and L3113-1 who are not covered by the provisions of article L1121-8
• Minors
• Adults under legal protection or unable to express their consent.
• A person who cannot read and understand the French language well enough to be able to consent to take part in research.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Assisitance Publique Hôpitaux de Marseille

Marseille, , France

Countries

France

Central Contacts

Régis Costello Pr

Role: CONTACT

promotion.interne@ap-hm.fr

0491435817 ext. 33

Facility Contacts

Régis Costello Pr

Role: primary

promotion.interne@ap-hm.fr

0491435817 ext. 33

Other Identifiers

2025-A01044-45

Identifier Type: OTHER

Identifier Source: secondary_id

RCAPHM25_0145

Identifier Type: -

Identifier Source: org_study_id