Don't Throw Your Heart Away: Layperson Study 1

NCT ID: NCT04133831

Last Updated: 2024-10-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 1019 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-11-15
• Study Completion Date: 2020-04-30

Brief Summary

Publicly available outcome assessments for transplant programs do not make salient that some programs tend to reject many of the hearts they are offered, whereas other programs accept a broader range of donor offers. The investigators use empirical studies to test whether transplant center performance data (i.e. transplant and waitlist outcome statistics) that reflect center donor acceptance rates influence laypersons to evaluate centers with high organ decline rates less favorably than centers with low organ decline rates. 1000 lay participants will be recruited from Amazon Mechanical Turk and randomized to one of five different information presentation conditions. Participants will be given an introduction to the donor organ match process, then asked to view the table of transplant outcomes corresponding to the condition they were randomized to. Each participant is asked to choose between two hospitals: one hospital with an non-selective, "accepting" strategy (takes all donor heart offers), and one hospital with a more selective, "cherrypicking" strategy (tends to reject donor offers that are less than "excellent" quality).

Detailed Description

Publicly available outcome assessments for transplant programs do not make salient that some programs tend to reject many of the hearts they are offered, whereas other programs accept a broader range of donor offers. The investigators use empirical studies to test whether transplant center performance data (i.e. transplant and waitlist outcome statistics) that reflect center donor acceptance rates influence laypersons to evaluate centers with high organ decline rates less favorably than centers with low organ decline rates. 1000 lay participants will be recruited from Amazon Mechanical Turk and randomized to one of five different information presentation conditions:

1. Condition 1 ("baseline" condition): view only combined transplant survival (e.g. transplant survival rate not stratified by number and quality of donor hearts accepted at each center)

2. Condition 2: view combined transplant survival + total survival (e.g. overall survival rate at each center, computed from survival rates of both transplant and waitlist patients)

3. Condition 3: view only stratified transplant survival (e.g. transplant survival rate stratified into patients who received excellent donor organs and patients who received less than optimal donor organs)

4. Condition 4: view stratified transplant survival + total survival

5. Condition 5: view only total survival

Participants will be given an introduction to the donor organ match process, then asked to view the table of transplant outcomes corresponding to the condition they were randomized to. Each participant is asked to choose between two hospitals: one hospital with an non-selective, "accepting" strategy (takes all donor heart offers), and one hospital with a more selective, "cherrypicking" strategy (tends to reject donor offers that are less than "excellent" quality). In order to identify the decision process that underlies this choice pattern, the investigators will examine a putative mediator. Specifically, participants will be asked to rate the extent to which they considered patients' chances of getting an excellent heart, avoiding a less-than-optimal heart, and getting any type of heart when making their choice between the two hospitals.

Conditions

Cardiac Transplant Disorder

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: SINGLE

Study Groups

Condition 1: Combined only

Participants randomized to baseline (control) arm Condition 1 will view only combined transplant survival outcome information (e.g. transplant survival rate not stratified by number and quality of donor hearts accepted at each center) when making a choice between the two hospitals.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Condition 2: Combined plus Total

Participants randomized to Condition 2 will view combined transplant survival and total survival outcome information when making a choice between the two hospitals.

Group Type: EXPERIMENTAL

Total Survival

Intervention Type: OTHER

The overall or "total" survival rate at each center is displayed in the table of outcome statistics.

Total survival is computed from survival rates of both transplant and waitlist patients: [(number of patients surviving after transplant at end of year + number of patients alive on waitlist at end of year)] / [number of patients alive on waitlist at start of year].

Condition 3: Stratified only

Participants randomized to Condition 3 will view only stratified transplant survival outcome information when making a choice between the two hospitals.

Group Type: EXPERIMENTAL

Stratified Transplant Survival

Intervention Type: OTHER

The transplant survival rate in the table of outcome statistics is stratified into two groups: (i) patients who received excellent donor organs and (ii) patients who received less than optimal donor organs.

Stratified transplant survival is computed from survival rates of transplant patients who received each quality category of organ.

excellent transplant survival = [number of patients surviving after transplant with excellent organ]/[number of patients for whom excellent organ was accepted for transplant] marginal transplant survival = [number of patients surviving after transplant with marginal organ]/[number of patients for whom marginal organ was accepted for transplant]

Condition 4: Stratified plus Total

Participants randomized to Condition 4 will view stratified transplant survival and total survival outcome information when making a choice between the two hospitals.

Group Type: EXPERIMENTAL

Total Survival

Intervention Type: OTHER

The overall or "total" survival rate at each center is displayed in the table of outcome statistics.

Total survival is computed from survival rates of both transplant and waitlist patients: [(number of patients surviving after transplant at end of year + number of patients alive on waitlist at end of year)] / [number of patients alive on waitlist at start of year].

Stratified Transplant Survival

Intervention Type: OTHER

The transplant survival rate in the table of outcome statistics is stratified into two groups: (i) patients who received excellent donor organs and (ii) patients who received less than optimal donor organs.

Stratified transplant survival is computed from survival rates of transplant patients who received each quality category of organ.

excellent transplant survival = [number of patients surviving after transplant with excellent organ]/[number of patients for whom excellent organ was accepted for transplant] marginal transplant survival = [number of patients surviving after transplant with marginal organ]/[number of patients for whom marginal organ was accepted for transplant]

Condition 5: Total only

Participants randomized to Condition 5 will view only total survival outcome information when making a choice between the two hospitals.

Group Type: EXPERIMENTAL

Total Survival

Intervention Type: OTHER

The overall or "total" survival rate at each center is displayed in the table of outcome statistics.

Total survival is computed from survival rates of both transplant and waitlist patients: [(number of patients surviving after transplant at end of year + number of patients alive on waitlist at end of year)] / [number of patients alive on waitlist at start of year].

Interventions

Total Survival

The overall or "total" survival rate at each center is displayed in the table of outcome statistics.

Total survival is computed from survival rates of both transplant and waitlist patients: [(number of patients surviving after transplant at end of year + number of patients alive on waitlist at end of year)] / [number of patients alive on waitlist at start of year].

Intervention Type: OTHER

Stratified Transplant Survival

The transplant survival rate in the table of outcome statistics is stratified into two groups: (i) patients who received excellent donor organs and (ii) patients who received less than optimal donor organs.

Stratified transplant survival is computed from survival rates of transplant patients who received each quality category of organ.

excellent transplant survival = [number of patients surviving after transplant with excellent organ]/[number of patients for whom excellent organ was accepted for transplant] marginal transplant survival = [number of patients surviving after transplant with marginal organ]/[number of patients for whom marginal organ was accepted for transplant]

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. 18 years of age or older

2. must read and understand the information in the consent form

3. must want to participate in the research and continue with the survey

4. must live in United States

Exclusion Criteria

1. Participants on mTurk will not be allowed to participate if they fail to pass the initial "bot screening", a multiple-choice question that asks, "What phone number should you dial when there is an emergency?" The obvious correct response in this screening question is "911", so participants who select one of the incorrect responses (i.e. "1-800-ANTIBOT", "1-877-MTURKER", "123") are filtered out and not allowed to complete the survey.

2. Participants on mTurk will be allowed to participate, but excluded from data analysis, if they submit a nonsense response to the free-response question which reads, "In your own words, why do you think patients should choose the hospital you picked?" This question takes place after the participant has viewed the choice stimuli and selected their response. If participants input nonsense in the text response box, they will be permitted to complete the survey and paid, but filtered out from the data analysis.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Carnegie Mellon University

OTHER

Sponsor Role: lead

Responsible Party

Gretchen Chapman

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Alison E Butler, BS

Role: PRINCIPAL_INVESTIGATOR

Carnegie Mellon University

Locations

Carnegie Mellon University

Pittsburgh, Pennsylvania, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

20PRE35120492

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

1F30HL152526-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1 F30 HL152526-01-A

Identifier Type: -

Identifier Source: org_study_id