Upper Limb Cross-education in Subacute Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-30

Study Completion Date

2019-07-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study evaluates how cross-education (unilateral training) affects muscle strength of the paretic limb in acute stroke patients. Half of the hemiplegic patients will receive conventional treatment and transcutaneous electrical nerve stimulation (TENS) to non-paretic side, while other half will receive conventional treatment and electro muscular stimulation (EMS) to non-paretic side.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Investigation of the Effects of Visual-Motor Based Training on Upper Extremity Functions in Individuals With Stroke

NCT07055945

Stroke

RECRUITING NA

Effects Of Sensory Training and Electrical Stimulation on Sole of The Foot Sensations in Patients With Acute Hemiplegia

NCT04252092

Hemiplegia Stroke, Acute Sensory Disorders

COMPLETED NA

Mirror Therapy and Cross-Education of Muscle Strength

NCT04887376

Cerebrovascular Stroke Muscle Weakness

COMPLETED NA

Abdominal Electrical Stimulation for Balance and Muscle Thickness in Stroke Patients

NCT07143630

Stroke

RECRUITING NA

Cold Therapy and Cross-Education of Muscle Strength

NCT04886843

Cerebrovascular Stroke Muscle Weakness

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Cross-education, which means the performance improvement in the untrained homologous muscle after unilateral exercise training, is studied in various orthopedical and neurological conditions affecting the body unilaterally. For those with asymmetrical weakness and immobility after stroke, training the non-paretic side can be utilized to increase the strength of the paretic side and improve functional symmetry. In this study, investigators aim was to examine whether training non-paretic upper extremity wrist flexor muscles by EMS in adjunct to conventional training program, has additional benefits upon the muscle powers of the homologous agonist and antagonist muscles. Investigators will use low frequency antalgic TENS stimulation at barely sensible level, which is considered not to cause muscle strengthening, as a control intervention.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hemiplegia Stroke

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

TENS group

30 sessions (5 sessions/week, 6 weeks) of training including 40 minutes of lower limb training including a mixture of lower limb gait training, balance training and aerobic training and a combination of task-oriented treatment, fine motor skill training, range of motion exercises stretch exercises and strength training (75% repetition maximum (RM), 6 repetitions) for 20 minutes. After that training program, patients will receive 30 minutes of conventional antalgic TENS (100 Hz) program as controls with electrostimulation device to the non-paretic wrist flexors.

Group Type SHAM_COMPARATOR

TENS

Intervention Type DEVICE

30 minutes of conventional antalgic TENS to non-paretic forearm

Conventional rehabilitation

Intervention Type PROCEDURE

40 minutes of lower limb training and 20 minutes of upper extremity training for stroke

EMS group

0 sessions (5 sessions/week, 6 weeks) of training including 40 minutes of lower limb training including a mixture of lower limb gait training, balance training and aerobic training and a combination of task-oriented treatment, fine motor skill training, range of motion exercises stretch exercises and strength training (75% repetition maximum (RM), 6 repetitions) for 20 minutes. After that training, the patients will receive 20 minutes of electrical stimulation to their non-paretic forearm upon wrist flexors by an intermittent maximum strength program (6 seconds of contraction, 10 seconds of rest) along with 5 minutes of pre and post warm-up with the same device.

Group Type ACTIVE_COMPARATOR

Conventional rehabilitation

Intervention Type PROCEDURE

40 minutes of lower limb training and 20 minutes of upper extremity training for stroke

EMS

Intervention Type DEVICE

20 minutes of EMS to non-paretic forearm with 5 minutes of pre and post warm-up

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

TENS

30 minutes of conventional antalgic TENS to non-paretic forearm

Intervention Type DEVICE

Conventional rehabilitation

40 minutes of lower limb training and 20 minutes of upper extremity training for stroke

Intervention Type PROCEDURE

EMS

20 minutes of EMS to non-paretic forearm with 5 minutes of pre and post warm-up

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* thromboembolic stroke,
* \<6 months of stroke,
* right hand dominancy,
* left hemiplegia,
* Brunnstrom stage ≥ 3 of recovery for upper extremity and hand

Exclusion Criteria

* myopathy, tendinopathy, peripheral neuropathy of the upper extremities,
* auditory, cognitive or speech disorder that enables communication,
* history of fracture or arthrodesis in the upper limb,
* contracture or severe spasticity (Ashworth scale ≥ 2) in forearm muscles,
* severe cardiovascular disorders (heart failure, coronary artery disease, drug resistant hypertension)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No