Electrical Stimulation During Immobilization

NCT ID: NCT01513486

Last Updated: 2013-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2013-01-31

Brief Summary

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In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.

Detailed Description

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Conditions

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Disuse Atrophy Immobilization Neuromuscular Electrical Stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Immobilization with NMES

Immobilization with daily NMES

Group Type EXPERIMENTAL

immobilization

Intervention Type BEHAVIORAL

Immobilization without NMES

Immobilization without daily NMES

Group Type PLACEBO_COMPARATOR

immobilization

Intervention Type BEHAVIORAL

Interventions

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immobilization

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Male
* Aged from 18-35 years
* 18.5 \< BMI \< 30 kg/m2

Exclusion Criteria

* Smoking
* Performing regular resistance training in the previous 6 months
* Hypertension (according to WHO criteria) \[46\] and/or cardiovascular disease
* Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
* Use of any prescribed medication
* Type 2 diabetes mellitus
* Any family history of thrombosis
* All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
* Myocardial infarction within the last 3 years
* Use of anti-coagulants
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Lex Verdijk

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Luc JC van Loon, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht UMC

Locations

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Maastricht University Medical Centre

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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MEC 11-3-073

Identifier Type: -

Identifier Source: org_study_id

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