Assessment of an Investigational Frequent Replacement Silicone Hydrogel Lens

NCT ID: NCT04085328

Last Updated: 2023-06-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

675 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-11

Study Completion Date

2021-03-26

Brief Summary

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The purpose of this clinical trial is to evaluate the safety and performance of an investigational soft contact lens compared to a commercially available soft contact lens when worn in an extended wear modality.

Detailed Description

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Subjects will be expected to attend 9 office visits. The total expected duration of participation for each subject is approximately 12 months.

Conditions

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Refractive Ametropia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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LID015385

LID015385 soft contact lenses worn in both eyes for up to 6 nights/7 days continuously (awake and asleep). Must sleep 1 night per week without lenses. Lenses will be replaced as specified in the study protocol.

Group Type EXPERIMENTAL

LID015385 soft contact lenses

Intervention Type DEVICE

Investigational silicone hydrogel contact lenses for up to 6 nights/7 days of continuous wear

Biofinity

Comfilcon A soft contact lenses worn in both eyes for up to 6 nights/7 days continuously (awake and asleep). Must sleep 1 night per week without lenses. Lenses will be replaced as specified in the study protocol.

Group Type ACTIVE_COMPARATOR

Comfilcon A soft contact lenses

Intervention Type DEVICE

Silicone hydrogel contact lenses for up to 6 nights/7 days of continuous wear

Interventions

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LID015385 soft contact lenses

Investigational silicone hydrogel contact lenses for up to 6 nights/7 days of continuous wear

Intervention Type DEVICE

Comfilcon A soft contact lenses

Silicone hydrogel contact lenses for up to 6 nights/7 days of continuous wear

Intervention Type DEVICE

Other Intervention Names

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BIOFINITY®

Eligibility Criteria

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Inclusion Criteria

* Able to understand and sign an Informed Consent Form.
* Willing to attend all scheduled study visits as required per protocol.
* Willing and able to wear assigned study lenses as required per protocol.
* Successful wear of spherical daily wear or extended wear frequent replacement soft contact lenses in both eyes during the past 3 months for a minimum of 5 days per week.
* Manifest cylinder ≤ 0.75 diopter (D) in each eye.

Exclusion Criteria

* Any eye infection, inflammation, or abnormality or disease (including systemic) that contraindicates contact lens wear, as determined by the Investigator.
* Any use of systemic or ocular medications for which contact lens wear could be contraindicated, as determined by the Investigator.
* History of eye surgery, including refractive surgery.
* Currently pregnant or breast-feeding.
* Monovision contact lens wearers.
* Daily disposable contact lens wearers.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alcon Study Director

Role: STUDY_DIRECTOR

Alcon Research

Locations

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Family EyeCare Center

Campbell, California, United States

Site Status

Winston Eye Care

Fullerton, California, United States

Site Status

Kurata Eye Care Center

Los Angeles, California, United States

Site Status

East West Eye Institute

Los Angeles, California, United States

Site Status

Dr.Elsa Pao, O.D

Oakland, California, United States

Site Status

Gordon Schanzlin New Vision Institute

San Diego, California, United States

Site Status

Complete Family Vision Care

San Diego, California, United States

Site Status

Westview Optometry

San Diego, California, United States

Site Status

OMEGA Vision Center PA, DBA Sabal Eye Care

Longwood, Florida, United States

Site Status

Kindred Optics at Maitland Vision Center

Maitland, Florida, United States

Site Status

Mid Florida Eye Center, PA

Mt. Dora, Florida, United States

Site Status

Eola Eyes

Orlando, Florida, United States

Site Status

Vision Health Institute

Orlando, Florida, United States

Site Status

Visual Performance Center Research & Development

Pensacola, Florida, United States

Site Status

Golden Vision

Sarasota, Florida, United States

Site Status

Advanced Eyecare Specialists

West Palm Beach, Florida, United States

Site Status

VisionPoint Eye Center

Bloomington, Illinois, United States

Site Status

Franklin Park Eye Center, PC

Franklin Park, Illinois, United States

Site Status

Kannarr Eye Care, LLC

Pittsburg, Kansas, United States

Site Status

Optimum Vision Care

Brighton, Massachusetts, United States

Site Status

Fraser Eye Care Center

Fraser, Michigan, United States

Site Status

Dr. Schwartz Optometrist and Associates

Sterling Heights, Michigan, United States

Site Status

Complete Eye Care of Medina

Medina, Minnesota, United States

Site Status

Fischer Laser Eye Center, LLC

Willmar, Minnesota, United States

Site Status

Tekwnai Vision Center, Inc

St Louis, Missouri, United States

Site Status

Alterman, Modi & Wolter

Poughkeepsie, New York, United States

Site Status

Rochester Ophthalmological Group, PC

Rochester, New York, United States

Site Status

Asheville Eye Associates, PLLC

Asheville, North Carolina, United States

Site Status

ProCare Vision Centers, Inc.

Granville, Ohio, United States

Site Status

Midwest Vision Care

Piqua, Ohio, United States

Site Status

EyeCare Professionals, Inc. DBA Insight Research Clinic, LLC

Powell, Ohio, United States

Site Status

Wyomissing Optometric Center

Wyomissing, Pennsylvania, United States

Site Status

West Bay Eye Associates

Warwick, Rhode Island, United States

Site Status

North Spartanburg Eye Center

Boiling Springs, South Carolina, United States

Site Status

Primary Eyecare Group, PC

Brentwood, Tennessee, United States

Site Status

Optometry Group, PLLC

Memphis, Tennessee, United States

Site Status

Total Eye Care, PA

Memphis, Tennessee, United States

Site Status

Advancing Vision Research, LLC

Smyrna, Tennessee, United States

Site Status

Beaumont Family Eye Care

Beaumont, Texas, United States

Site Status

Vision One Eyecare

Katy, Texas, United States

Site Status

Dawn M Rakich, OD

San Antonio, Texas, United States

Site Status

Clarke EyeCare Center

Wichita Falls, Texas, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CLL949-C010

Identifier Type: -

Identifier Source: org_study_id

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