Clinical Evaluation of a Silicone Hydrogel Daily Wear Monthly Replacement Contact Lens

NCT ID: NCT04422990

Last Updated: 2022-03-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

158 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-01

Study Completion Date

2021-05-18

Brief Summary

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The purpose of this clinical study is to evaluate the safety and performance of an investigational soft contact lens compared to a commercially available soft contact lens when worn in a daily wear modality.

Detailed Description

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Subjects will be expected to attend 4 office visits: Screening/Baseline/Dispense, Week 1 Follow-up, Month 1 Follow-up, and Month 3 Follow-up/Exit. The total expected duration of participation for each subject is approximately 3-4 months in this daily wear clinical study.

Conditions

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Refractive Errors

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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LID018869

Lehfilcon A silicone hydrogel contact lenses worn in both eyes during waking hours only. Lenses will be worn for a total of 3 months, with monthly planned replacement over the course of the study duration. CLEAR CARE will be used for nightly contact lens cleaning and disinfection.

Group Type EXPERIMENTAL

Lehfilcon A contact lenses

Intervention Type DEVICE

Investigational silicone hydrogel contact lenses

CLEAR CARE

Intervention Type DEVICE

Hydrogen peroxide-based contact lens cleaning and disinfecting solution

Biofinity

Comfilcon A silicone hydrogel contact lenses worn in both eyes during waking hours only. Lenses will be worn for a total of 3 months, with monthly planned replacement over the course of the study duration. CLEAR CARE will be used for nightly contact lens cleaning and disinfection.

Group Type ACTIVE_COMPARATOR

Comfilcon A contact lenses

Intervention Type DEVICE

Commercially available silicone hydrogel contact lenses

CLEAR CARE

Intervention Type DEVICE

Hydrogen peroxide-based contact lens cleaning and disinfecting solution

Interventions

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Lehfilcon A contact lenses

Investigational silicone hydrogel contact lenses

Intervention Type DEVICE

Comfilcon A contact lenses

Commercially available silicone hydrogel contact lenses

Intervention Type DEVICE

CLEAR CARE

Hydrogen peroxide-based contact lens cleaning and disinfecting solution

Intervention Type DEVICE

Other Intervention Names

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LID018869 CooperVision® BIOFINITY® Biofinity

Eligibility Criteria

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Inclusion Criteria

* Successful wear of spherical daily wear frequent replacement soft contact lenses for distance correction in both eyes during the past 3 months for a minimum of 5 days per week and 8 hours per day;
* Manifest cylinder equal to or less than 0.75 diopter (D) in each eye;
* Best spectacle corrected visual acuity (using manifest refraction) of 20/20 or better in each eye;

Exclusion Criteria

* Wearing habitual contact lenses in an extended wear modality (routinely sleeping in lenses for at least 1 night per week) over the last 3 months prior to enrollment;
* Habitually wearing Biofinity lenses;
* Monovision or multifocal contact lens wearers;
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sr. Clinical Trial Lead, CDMA Vision Care

Role: STUDY_DIRECTOR

Alcon Research, LLC

Locations

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Alcon Investigative Site

Los Angeles, California, United States

Site Status

Alcon Investigative Site

Novato, California, United States

Site Status

Alcon Investigative Site

Oakland, California, United States

Site Status

Alcon Investigative Site

Oakland, California, United States

Site Status

Alcon Investigative Site

San Francisco, California, United States

Site Status

Alcon Investigative Site

Orlando, Florida, United States

Site Status

Alcon Investigative Site

West Palm Beach, Florida, United States

Site Status

Alcon Investigative Site

Downers Grove, Illinois, United States

Site Status

Alcon Investigative Site

Louisville, Kentucky, United States

Site Status

Alcon Investigative Site

New York, New York, United States

Site Status

Alcon Investigative Site

Cleveland, Ohio, United States

Site Status

Alcon Investigative Site

Boiling Springs, South Carolina, United States

Site Status

Alcon Investigative Site

Plano, Texas, United States

Site Status

Alcon Investigative Site

Wichita Falls, Texas, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CLY935-C012

Identifier Type: -

Identifier Source: org_study_id

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