Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery
NCT ID: NCT04076709
Last Updated: 2025-04-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
34 participants
INTERVENTIONAL
2020-09-01
2025-03-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Standard Care
No interventions assigned to this group
Goal directed anesthesia
Deep neuromuscular blockade (post tetanic count 1-2 twitches) and nociception guided anaesthesia
goal directed anaesthesia
Deep neuromuscular blockade (PTC 1-2) Nociception level index (NOL) target 10-25
Interventions
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goal directed anaesthesia
Deep neuromuscular blockade (PTC 1-2) Nociception level index (NOL) target 10-25
Eligibility Criteria
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Inclusion Criteria
* Scheduled for lower laparoscopic abdominal surgery;
* Ability to give oral and written consent;
Exclusion Criteria
* Allergies to muscle relaxants, anesthetics or narcotics;
* A (family) history of malignant hyperthermia;
* Women who are or may be pregnant;
* Preexisting cardiac disease (any);
* Untreated or uncontrolled hypertension;
* COPD gold 3 or higher
* Preexistent esophageal pathology (stricture, tumor, diverticulum)
* Any increased risk factor for upper gastro intestinal tract bleed:
* History of GI surgery;
* History of GI bleed;
* Esophageal varices;
* Gastric or esophageal inflammation;
* Severe thrombocytopenia (less than 50k) or severely elevated INR (\>4).
18 Years
ALL
No
Sponsors
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Leiden University Medical Center
OTHER
Responsible Party
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Martijn Boon
Principle Investigator
Locations
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Leiden University Medical Center
Leiden, , Netherlands
Countries
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Other Identifiers
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P19.042
Identifier Type: -
Identifier Source: org_study_id
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