This Study Assess Some Physiological Parameters, Blood Picture, and Hemodynamic Parameters, Blood Pressure, Respiratory Assess by SPO2, During Different Periods in Laparoscopic Surgery

NCT ID: NCT06473194

Last Updated: 2024-06-25

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-10-01
• Study Completion Date: 2026-11-01

Brief Summary

Laparoscopic surgery is widely used now. These benefits included many items, e.g. reducing post-operative pain, cosmetic the result was improved, and the patient also had more satisfaction for the patient and reduced hospital stay. This surgery involved insufflation of gas into the peritoneal cavity, producing pneumoperitoneum, and causing an increase in intra-abdominal pressure. The raised intraabdominal pressure of the pneumoperitoneum, the patient's position alteration, and the absorption of carbon dioxide into the abdomen have a direct effect on causing a change in physiology, especially in the cardiovascular and respiratory systems. These effects, as well as a direct effect of gas insufflation, may have significant effects on the patient especially if the patient has a comorbidity or is elderly.

Detailed Description

The objective of this study was to assess the technique used in laparoscopic surgery and their associated complications, including some hematological parameters, (these include blood pictures and liver enzymes), respiratory, (including the inspired and expired tidal volume, oxygen saturation, airway pressure, plateau pressure, and use of PEEP) cardiovascular system (including the systolic, diastolic, and mean blood pressure, heart rate)

Conditions

Anesthesia Complication; Physiological Parameter

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

age , gender

group according to age and according to gender

Group Type: EXPERIMENTAL

general anesthesia drug (like Propofol, esmeron, and ketamin, .effects of pneumoperitoneum

Intervention Type: PROCEDURE

this research will involve the selection of elective cases with ASA class I or II and assessment of patients with respiratory cardiovascular parameters and hematology perioperative

Interventions

general anesthesia drug (like Propofol, esmeron, and ketamin, .effects of pneumoperitoneum

this research will involve the selection of elective cases with ASA class I or II and assessment of patients with respiratory cardiovascular parameters and hematology perioperative

Intervention Type: PROCEDURE

Other Intervention Names

monitoring in anesthesia to asses hemodynamic parameter includes blood pressure, pulse rate, and SPO2, compared with biochemical blood sugar, liver enzyme, respiratory alteration by end-tidal CO2

Eligibility Criteria

Inclusion Criteria

1. elective abdominal surgery

2. a healthy, fit person

3. use of general anesthetics

4. use of pneumoperitoneum and CO2 insufflation

Exclusion Criteria

1. emergency condition

2. patient with cardiovascular disease

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Mohammed Abdulhameed

OTHER

Sponsor Role: lead

Responsible Party

Mohammed Abdulhameed

principal investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

hussam Mu. Kareem, PHD

Role: STUDY_DIRECTOR

Ministry of Health

Central Contacts

Mohammed Ab. younis, PHD

Role: CONTACT

mohammedhameed330@gmail.com

009647801870904

wissem H. HMIDA, PROFF.

Role: CONTACT

hmidawissem@gmail.com

+21698452331

References

Celep RB, Kahramanca S, Ozsoy M, Azili C, Cetinkunar S, Hasdemir AO, Guzel H, Ozgehan G, Colhan I, Kucukpinar TH. Effects of intraabdominal pressure on mean platelet volume during laparoscopic cholecystectomy. Turk J Med Sci. 2014;44(3):360-4. doi: 10.3906/sag-1304-23.

Reference Type: BACKGROUND

PMID: 25558633 (View on PubMed)

Bitkin A, Aydin M, Irkilata L, Keles M, Akgunes E, Ocak S, Atilla MK. Effect of Intra-abdominal Pressure Rise on Hematological Parameters in Laparoscopic Urologic Surgery. J Coll Physicians Surg Pak. 2018 Sep;28(9):699-702. doi: 10.29271/jcpsp.2018.09.699.

Reference Type: BACKGROUND

PMID: 30158037 (View on PubMed)

Sen MC, Turkyilmaz Z, Sonmez K, Karabulut R, Kaya Z, Yenicesu I, Gursel T, Basaklar AC. The Effect of Carbon Dioxide Insufflation Applied at Different Pressures and Periods on Thrombotic Factors. Indian J Hematol Blood Transfus. 2016 Mar;32(1):87-91. doi: 10.1007/s12288-015-0517-2. Epub 2015 Feb 15.

Reference Type: BACKGROUND

PMID: 26855512 (View on PubMed)

Crema E, Ribeiro EN, Hial AM, Alves Junior JT, Pastore R, Silva AA. Evaluation of the response of cortisol, corticotropin and blood platelets kinetics after laparoscopic and open cholecystectomy. Acta Cir Bras. 2005 Sep-Oct;20(5):364-7. doi: 10.1590/s0102-86502005000500005. Epub 2005 Sep 5.

Reference Type: BACKGROUND

PMID: 16186960 (View on PubMed)

Hasukic S, Kosuta D, Muminhodzic K. Comparison of postoperative hepatic function between laparoscopic and open cholecystectomy. Med Princ Pract. 2005 May-Jun;14(3):147-50. doi: 10.1159/000084630.

Reference Type: BACKGROUND

PMID: 15863986 (View on PubMed)

Other Identifiers

physiological measurement

Identifier Type: -

Identifier Source: org_study_id