Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

NCT ID: NCT04074278

Last Updated: 2019-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-01

Study Completion Date

2015-12-01

Brief Summary

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Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD).

Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

Detailed Description

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Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.

Conditions

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Lean Body Mass Chronic Kidney Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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development groups

The development groups included 150 patients derived from outpatients in Peking University First Hospital, between March 1st, 2014 and November 26th 2014.

No interventions assigned to this group

validation groups

The validation groups included 150 patients derived from outpatients in Peking University First Hospital, between November 27th 2014 and December 1st, 2015.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* non-dialyzed patients with CKD stage 3-5
* clinical stable
* a willingness to be examined with all measurements being taken simultaneously.

Exclusion Criteria

* systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor
* severe edema within one month prior to the study
* chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy,
* taking immunosuppressive agents and anti-inflammatory medication chronically
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University First Hospital

OTHER

Sponsor Role lead

Responsible Party

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Dong Jie

Clinical Professor of Institute of Nephrology, Division of Renal

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Renal Division and Institute of Nephrology, Peking University First Hospital

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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LBM eqations

Identifier Type: -

Identifier Source: org_study_id

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