SA Versus SOI Surfaces for Single Implant-supported Crown

NCT ID: NCT04073654

Last Updated: 2019-10-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-26

Study Completion Date

2021-10-15

Brief Summary

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The purpose of this randomized controlled trial is to compare clinical data and implant stability of immediately loaded TSIII Osstem implants with Sandblasted and Acid-etched (SA) surface versus implants with SA surface modified with pH buffering agent for the rehabilitation of single implant-supported crown.

Detailed Description

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This study aimed to evaluate if there are some benefits using novel implant surface. This surface should improve the secondary implant stability, reducing the overall time needed for the osseointegration. main benefits in clinical practice should be reduced treatment time.

Conditions

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Dental Implant Failed Bone Resorption

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized controlled trial, split-mouth design
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors
Implants have same macro design.

Study Groups

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SA Implants

Dental implant with sandblasted and Acid-etched (SA) surface

Group Type ACTIVE_COMPARATOR

Placement of dental implants (surgical procedure)

Intervention Type PROCEDURE

The two study implants have to be placed in the same surgical session according to similar procedures. Implants will be placed in the planned anatomic sites by using a flapless or a miniflap approach. Implants sites will be prepared based on the bone density, and according to the manufacturers's instruction by using the 122 Taper kit (Osstem Implant).

SOI Implants

Same dental implant with sandblasted and Acid-etched surface modified with pH buffering agent

Group Type EXPERIMENTAL

Placement of dental implants (surgical procedure)

Intervention Type PROCEDURE

The two study implants have to be placed in the same surgical session according to similar procedures. Implants will be placed in the planned anatomic sites by using a flapless or a miniflap approach. Implants sites will be prepared based on the bone density, and according to the manufacturers's instruction by using the 122 Taper kit (Osstem Implant).

Interventions

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Placement of dental implants (surgical procedure)

The two study implants have to be placed in the same surgical session according to similar procedures. Implants will be placed in the planned anatomic sites by using a flapless or a miniflap approach. Implants sites will be prepared based on the bone density, and according to the manufacturers's instruction by using the 122 Taper kit (Osstem Implant).

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Any partially edentulous subject requiring at least two single (preferable non-adjacent) implant-supported crowns, being at least 18 year old and able to sign an informed consent will be screened for eligibility. Bone volumes should allow the placement of two implants at least 8.5 mm (maximum 10 mm) long and 4.5 mm (minimum 3.5 mm) wide, with a minimal insertion torque of 30 Ncm. Implants can be placed in previous post-extractive socket or in augmented bone, if at least 4 to 6 months have passed from the extraction or from augmentation procedures.

Exclusion Criteria

* Patients unable to commit to 5 years follow-up.
* General contraindications to implant surgery.
* Less then 4 mm of keratinised gingiva crestally (at the implant sites).
* Immune-suppressed/compromised patients.
* Patients irradiated in the head and/or neck.
* Uncontrolled diabetes.
* Pregnancy or lactation.
* Untreated periodontal disease.
* Poor oral hygiene and motivation (full mouth bleeding and full mouth plaque index higher than 25%).
* Addiction to alcohol or drugs.
* Psychiatric problems and/or unrealistic expectations.
* Patients with an acute infection or suppuration in the site intended for implant placement.
* Patients needing any form of tissue augmentation at implant placement.
* Immediate post-extractive implants (implants can be placed after a 3-month healing period).
* Patients treated or under treatment with intravenous amino-bisphosphonates.
* Patients referred only for implant placement if the follow-up cannot be done at the treatment center.
* Patients participating in other studies, if the present protocol could not be fully adhered to.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Osstem AIC

OTHER

Sponsor Role lead

Responsible Party

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Marco Tallarico

Coordinator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Erta Xhanari

Tirana, , Albania

Site Status RECRUITING

Elitsa Deliverska

Sofia, , Bulgaria

Site Status RECRUITING

Fulvio Gatti

Milan, , Italy

Site Status RECRUITING

Studio Odontoiatrico Marco Tallarico

Rome, , Italy

Site Status RECRUITING

Leonardo Muzzi

Siena, , Italy

Site Status RECRUITING

Łukasz Zadrożny

Warsaw, , Poland

Site Status RECRUITING

Cesaltino Remedios

Fátima, , Portugal

Site Status RECRUITING

Mircea

Craiova, , Romania

Site Status RECRUITING

Andre de Waal

South Africa, , South Africa

Site Status RECRUITING

Nicolas Widmer

Bern, , Switzerland

Site Status RECRUITING

Countries

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Albania Bulgaria Italy Poland Portugal Romania South Africa Switzerland

Central Contacts

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Marco Tallarico

Role: CONTACT

+3280758769

Facility Contacts

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Erta Xhanari

Role: primary

Elitsa Deliverska

Role: primary

Fulvio Gatti, Dr

Role: primary

+39 ‭339 6441920‬

Marco Tallarico, Dr

Role: primary

+39 066630646

Leonardo Muzzi

Role: primary

Łukasz Zadrożny

Role: primary

Cesaltino Remedios

Role: primary

Mircea Gheorghita

Role: primary

Andre de Waal

Role: primary

Nicolas Widmer

Role: primary

Other Identifiers

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SOI_1_RCT_MT

Identifier Type: -

Identifier Source: org_study_id

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