Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2018-07-10
2019-07-09
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Single arm
Body-weight supported treadmill training in a room cooled to 16°C
A total of 30 training sessions will be conducted in 10 weeks for 30 minutes per session and 3 times per week in a cool room (16⁰ C) on a treadmill that is equipped with safety straps to prevent falls. A pneumatic harness system will be used to provide 10% body-weight support during training sessions. The participants will start exercising on the treadmill at 80% of their self-selected walking speed with 1% incline and will increase as per their tolerance (will progress weekly based on 40-65% heart rate reserve). Heart rate, perceived fatigue and rating of perceived exertion will be monitored continuously during exercise sessions. Initial training will commence with intermittent rest periods \[1 to 5 minutes\] as requested by the participants and will be progressed to a maximum of 30-minute continuous treadmill walking.
Interventions
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Body-weight supported treadmill training in a room cooled to 16°C
A total of 30 training sessions will be conducted in 10 weeks for 30 minutes per session and 3 times per week in a cool room (16⁰ C) on a treadmill that is equipped with safety straps to prevent falls. A pneumatic harness system will be used to provide 10% body-weight support during training sessions. The participants will start exercising on the treadmill at 80% of their self-selected walking speed with 1% incline and will increase as per their tolerance (will progress weekly based on 40-65% heart rate reserve). Heart rate, perceived fatigue and rating of perceived exertion will be monitored continuously during exercise sessions. Initial training will commence with intermittent rest periods \[1 to 5 minutes\] as requested by the participants and will be progressed to a maximum of 30-minute continuous treadmill walking.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* relapse-free in the previous 3 months
* requiring ambulatory assistive devices (EDSS 6.0-7.0)
* negative PAR-Q screen for risk factors
* greater than 6-weeks post Botulinum Toxin injection (if received) in the lower extremity
Exclusion Criteria
* finished a drug/device study in the last 30 days
* over 75 years of age
* unable to control bowel and bladder on physical exertion
* currently attending physical rehabilitation
* having no difficulty walking in the community (self-selected walking speed \>120 cm/s)
18 Years
75 Years
ALL
No
Sponsors
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Memorial University of Newfoundland
OTHER
Responsible Party
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Michelle Ploughman
Assistant Professor of Medicine
Locations
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Memorial University of Newfoundland
St. John's, Newfoundland and Labrador, Canada
Countries
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References
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Chaves AR, Devasahayam AJ, Kelly LP, Pretty RW, Ploughman M. Exercise-Induced Brain Excitability Changes in Progressive Multiple Sclerosis: A Pilot Study. J Neurol Phys Ther. 2020 Apr;44(2):132-144. doi: 10.1097/NPT.0000000000000308.
Devasahayam AJ, Chaves AR, Lasisi WO, Curtis ME, Wadden KP, Kelly LP, Pretty R, Chen A, Wallack EM, Newell CJ, Williams JB, Kenny H, Downer MB, McCarthy J, Moore CS, Ploughman M. Vigorous cool room treadmill training to improve walking ability in people with multiple sclerosis who use ambulatory assistive devices: a feasibility study. BMC Neurol. 2020 Jan 22;20(1):33. doi: 10.1186/s12883-020-1611-0.
Other Identifiers
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2018.088
Identifier Type: -
Identifier Source: org_study_id
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