Study Results
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Basic Information
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COMPLETED
NA
117 participants
INTERVENTIONAL
2019-02-25
2021-04-20
Brief Summary
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Moreover, Parkinson' patients could display an impairment of gait and cognitive function. Attentional task and dual task situation are particularly impaired in this pathology. This is why the investigators of Orleans's hospital want to also examine cerebral activation of these patients during walking and during a dual task.
The hemodynamic cerebral activation will be studied using the near infrared spectroscopy at the level of the prefrontal cortex. This non-invasive technic allows the evaluation of the regional oxyhemoglobin and deoxyhemoglobin variations induced by cerebral activation.
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Detailed Description
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For that, 160 participants (females and males) will be included and 8 groups will be constituted (woman and man non active young people, woman and man non active old people, woman and man active old people, woman and man patients with Parkinson's disease).
Every participants will performed a set of 6 tasks of 2 minutes. Each task will be separated by a 2 minutes resting period. The tasks will be a cognitive task, a control cognitive task, walking at 3 kilometers/hour, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
During the set, prefrontal oxygenation will be measured using the near infrared spectroscopy.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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women non active young people
women between 18 and 30 years practice less than 1h of physical activity per week
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
men non active young people
men between 18 and 30 years practice less than 1h of physical activity per week
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
women non active old people
women between 60 and 85 years practice less than 1h of physical activity per week
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
men non active old people
men between 60 and 85 years practice less than 1h of physical activity per week
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
women active old people
women between 60 and 85 years practice at least 3h of physical activity per week
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
men active old people
men between 60 and 85 years practice at least 3h of physical activity per week
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
women with parkinson's disease
women between 60 and 85 years presence of the disease according to the criteria of the UK Parkinson Disease Brain Bank
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
men with parkinson's disease
men between 60 and 85 years presence of the disease according to the criteria of the UK Parkinson Disease Brain Bank
walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
Interventions
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walking
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be walking at 3 km/h, walking while doing the cognitive task, walking at the preferred speed, walking at the preferred speed while doing the cognitive task.
cognitive task
Every participants will performed a set of tasks of 2 min. Each task will be separated by a 2 min resting period. The tasks will be a cognitive task, a control cognitive task.
Eligibility Criteria
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Inclusion Criteria
* men and women active old people: practice at least 3 hours of physical activity per week
For all subjects:
* Resting electrocardiographic abnormality, Systolic blood pressure \>16
* Heart disease, recent and unusual shortness of breath or needing several pillows to sleep at night, effort/rest chest pain, palpitations with effort, history of discomfort with effort
* Respiratory failure
* Disabling rheumatological pathology for walking
* Neuro-progressive disease or sequelae
* Perceptual disorders
* Medication (neuroleptics, psychotropic treatment modifying alertness) potentially having an impact on walking
* Thickness of the skin fold at the vast lateral area greater than 15 mm
* Inability of the volunteer to perform the Random Generation of Numbers task for at least 1 min or frequency of enunciation numbers during the Random Generation of Numbers task \> 4/s
* Refusal to sign informed consent
For the young sedentary group (woman and man) and the senior group (woman and man, sedentary and active):
-Subjective health \> 3 out of 5
For the senior group (woman and man, sedentary and active):
* Mini-Mental State Evaluation (MMSE) score \< 24
* Geriatric Depression Scale (GDS) score \> 10
For the Parkinson group (woman and man):
* Presence of a freezing or clinically embarrassing festination (walking disorder)
* Score of Hoehn and Yahr ≥III
Exclusion Criteria
18 Years
30 Years
ALL
Yes
Sponsors
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Centre Hospitalier Régional d'Orléans
OTHER
Responsible Party
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Principal Investigators
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Pascal AUZOU, MD
Role: PRINCIPAL_INVESTIGATOR
CHR orléans
Locations
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CHR Orléans
Orléans, , France
Countries
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References
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Anderton BH. Ageing of the brain. Mech Ageing Dev. 2002 Apr;123(7):811-7. doi: 10.1016/s0047-6374(01)00426-2.
Andres P, Van der Linden M. Age-related differences in supervisory attentional system functions. J Gerontol B Psychol Sci Soc Sci. 2000 Nov;55(6):P373-80. doi: 10.1093/geronb/55.6.p373.
Asllani I, Habeck C, Borogovac A, Brown TR, Brickman AM, Stern Y. Separating function from structure in perfusion imaging of the aging brain. Hum Brain Mapp. 2009 Sep;30(9):2927-35. doi: 10.1002/hbm.20719.
Azulay JP, Van Den Brand C, Mestre D, Blin O, Sangla I, Pouget J, Serratrice G. [Automatic motion analysis of gait in patients with Parkinson disease: effects of levodopa and visual stimulations]. Rev Neurol (Paris). 1996 Feb;152(2):128-34. French.
Other Identifiers
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CHRO-2018-11
Identifier Type: -
Identifier Source: org_study_id
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