Diaphragm Ultrasound in Neuromuscular Disorders

NCT ID: NCT04045158

Last Updated: 2019-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-15

Study Completion Date

2020-05-10

Brief Summary

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Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function.

The aims of the study are:

* to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies
* to assess the correlation between diaphragm ultrasound and FPT
* to assess the correlation between diaphragm ultrasound and cardiac function

Detailed Description

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Conditions

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Muscular Dystrophies

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Duchenne muscular dystrophy,
* Becker muscular dystrophy,
* LGMD,
* myotonic dystrophy type 1 and type 2,
* metabolic myopathy,
* mitochondrial myopathy,
* FSHD1 and 2,
* myasthenia

Exclusion Criteria

* history of cardiac surgery
* history of thoracic surgery
* brain traumatism
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre d'Investigation Clinique et Technologique 805

OTHER

Sponsor Role lead

Responsible Party

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Abdallah FAYSSOIL

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hopital Raymond Poincare

Garches, , France

Site Status

Countries

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France

References

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Fayssoil A, Nguyen LS, Stojkovic T, Prigent H, Carlier R, Amthor H, Bergounioux J, Zini J, Damez-Fontaine S, Wahbi K, Laforet P, Nicolas G, Behin A, Bassez G, Leturcq F, Ben Yaou R, Mansencal N, Annane D, Lofaso F, Orlikowski D. Determinants of diaphragm inspiratory motion, diaphragm thickening, and its performance for predicting respiratory restrictive pattern in Duchenne muscular dystrophy. Muscle Nerve. 2022 Jan;65(1):89-95. doi: 10.1002/mus.27432. Epub 2021 Oct 25.

Reference Type DERIVED
PMID: 34618930 (View on PubMed)

Other Identifiers

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DIAPH-NMD

Identifier Type: -

Identifier Source: org_study_id

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