Development of the Effectiveness of Rehabilitation Tools for Neurovisual Disorders in Patients With Posterior Cortical Atrophy

NCT ID: NCT04041089

Last Updated: 2023-03-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 3 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-09-02
• Study Completion Date: 2022-06-15

Brief Summary

Posterior cortical atrophy (PCA) is manifested by neuro-visual disorders that alter the spatial location of objects, their manipulation and/or recognition. Its etiology is most often neurodegenerative, with a major impact on the autonomy and mood of patients and their families. Few studies have focused on non-medication management of these disorders.

The present study thus has a double objective: the development of a complete tool to work on the recognition, localization and/or manipulation of objects; and the evaluation of the effectiveness of this type of management.

Conditions

Posterior Cortical Atrophy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Recognition of objects

Patients will do the therapy in the following order: object location, object manipulation and object recognition

Group Type: EXPERIMENTAL

Recognition of objects

Intervention Type: BEHAVIORAL

• Name of shapes / colors / images / objects
• Classification of shapes / colors / images / objects

Location of objects

Patients will do the therapy in the following order: object recognition, object location, and object manipulation

Group Type: EXPERIMENTAL

Location of objects

Intervention Type: BEHAVIORAL

• Search for frequent/rarse targets among distractors sharing one or more characteristics with the target
• Hit/catch a stationary/mobile target as quickly as possible

Manipulation of objects

Patients will do the therapy in the following order: object manipulation, object recognition and object location

Group Type: EXPERIMENTAL

Manipulation of objects

Intervention Type: BEHAVIORAL

• Storage of shapes/objects
• Use of everyday objects (pen, cutlery, etc.)

Interventions

Recognition of objects

• Name of shapes / colors / images / objects
• Classification of shapes / colors / images / objects

Intervention Type: BEHAVIORAL

Location of objects

• Search for frequent/rarse targets among distractors sharing one or more characteristics with the target
• Hit/catch a stationary/mobile target as quickly as possible

Intervention Type: BEHAVIORAL

Manipulation of objects

• Storage of shapes/objects
• Use of everyday objects (pen, cutlery, etc.)

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Age >50 years old
• Male or Female
• Patients with a diagnosis of PCA according to the criteria of Tang-Wai et al (2004)
• MMS>15
• Voluntary, written and informed consent of the patient himself or its legal representative (guardian/curator), with oral consent of the patient in all cases
• Anti-Alzheimer's and psychotropic treatments stable for one month, if taken by the patient
• Affiliation to a social security system

Exclusion Criteria

• Uncorrected visual disorders with non-degenerative etiology (AV<0.5)
• Person under the protection of justice
• Pregnant women (a pregnancy test will be performed in premenopausal women)

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier Universitaire de Nice

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

MOUTON Aurélie, Ph

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Nice

Locations

Institut Claude Pompidou - Centre Mémoire de Ressources et de Recherche du CHU de Nice

Nice, Alpes-Maritime, France

Countries

France

Other Identifiers

18-AOI-02

Identifier Type: -

Identifier Source: org_study_id