Action Observation and Motor Imagery Therapy in Parkinson's Disease

NCT ID: NCT06154356

Last Updated: 2023-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-14

Study Completion Date

2024-12-30

Brief Summary

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In recent years, motor imagery (MI) and action observation (AO) therapy strategies have been used in rehabilitation programs to increase motor learning in Parkinson's disease (PD). Visuomotor training strategies such as AO and MI therapy rely on the activity of the mirror neuron system to facilitate motor re-learning. Mirror neurons are activated during the performance of goal-directed actions, also when observing the same action and visualizing the action in the mind.

The aim of this clinical trial is to test whether the application of AO and MI treatment in PD in addition to conventional rehabilitation programs has an additional effect on Balance, Functional Status and Quality of Life.

Detailed Description

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Parkinson's disease (PD) is a neurodegenerative disease with a chronic and progressive course. Freezing phenomena, gait disorders, and balance problems are common in PD. Gait and balance disorders and motor freezing attacks that occur as a result of PD increase the risk of falling, leading to a decrease in functional independence and quality of life. The main goal of Parkinson's rehabilitation is to ensure the maximum functional status and independence in daily living activities and to increase their quality of life.

In recent years, motor imagery (MI) and action observation (AO) therapy strategies have been used in rehabilitation programs to increase motor learning in PD. Visuomotor training strategies such as AO and MI therapy rely on the activity of the mirror neuron system to facilitate motor re-learning. Mirror neurons are activated during the performance of goal-directed actions, also when observing the same action and visualizing the action in the mind.

The aim of this clinical trial is to test whether the application of AO and MI treatment in PD in addition to conventional rehabilitation programs has an additional effect on Balance, Functional Status and Quality of Life.

Conditions

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Parkinson's Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Prospective randomized controlled study
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Action observation and motor imagery therapy for rehabilitation

Action observation and motor imagery therapy for rehabilitation in Parkinson's Disease in addition to conventional rehabilitation programs.

Group Type EXPERIMENTAL

Action observation and motor imagery therapy for rehabilitation

Intervention Type OTHER

Action observation; Patients will watch some exercises accompanied by music from a previously prepared video for 10 minutes. Exercises include 8-10 repetitions of abduction-adduction, horizontal abduction-adduction, flexion-extension and supination-pronation movements for the upper extremity, and stepping, forward-backward stepping, side stepping and ankle dorsiflexion movements for the lower extremity.

Motor imagery training; Patients will be asked to visualize the actions they watched in their minds for 10 minutes.

Then the patients will watch the video again and will be asked to perform the exercises while watching.

Sham action observation and motor imagery therapy for rehabilitation

Sham comparator for action observation and motor imagery therapy for rehabilitation in Parkinson's Disease in addition to conventional rehabilitation programs.

Group Type SHAM_COMPARATOR

Sham action observation and motor imagery therapy for rehabilitation

Intervention Type OTHER

Sham action observation; Patients will watch a video consisting of static nature photographs for 10 minutes with the same music.

Sham motor imaginary; Patients will think about the video they watched for 10 minutes.

Then, they will watch another video in which the exercises are performed only once, and they will be asked to do the exercises. They will be given enough time to do 8-10 repetitions.

Interventions

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Action observation and motor imagery therapy for rehabilitation

Action observation; Patients will watch some exercises accompanied by music from a previously prepared video for 10 minutes. Exercises include 8-10 repetitions of abduction-adduction, horizontal abduction-adduction, flexion-extension and supination-pronation movements for the upper extremity, and stepping, forward-backward stepping, side stepping and ankle dorsiflexion movements for the lower extremity.

Motor imagery training; Patients will be asked to visualize the actions they watched in their minds for 10 minutes.

Then the patients will watch the video again and will be asked to perform the exercises while watching.

Intervention Type OTHER

Sham action observation and motor imagery therapy for rehabilitation

Sham action observation; Patients will watch a video consisting of static nature photographs for 10 minutes with the same music.

Sham motor imaginary; Patients will think about the video they watched for 10 minutes.

Then, they will watch another video in which the exercises are performed only once, and they will be asked to do the exercises. They will be given enough time to do 8-10 repetitions.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with a diagnosis of Parkinson's Disease
* Hoehn and Yahr Stage 1-3

Exclusion Criteria

* Patients with cognitive dysfunction (those who cannot follow simple verbal instructions)
* Patients with severe hearing problems
* Patients with severe vision problems
* Patients with additional musculoskeletal system pathology that will affect physical performance (such as amputation, severe joint mobility limitation, peripheral nerve damage)
* Patients with uncontrolled hypertension and diabetes mellitus
* Patients with a history of symptomatic lung disease (such as asthma, chronic obstructive pulmonary disease, emphysema)
* Patients with a history of symptomatic cardiac disease (such as coronary artery disease, arrhythmia, heart failure)
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karaman Training and Research Hospital

OTHER

Sponsor Role collaborator

Karamanoğlu Mehmetbey University

OTHER

Sponsor Role lead

Responsible Party

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Yurdagül Bahran Muştu

M.D., Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yurdagul Bahran Mustu, MD.

Role: PRINCIPAL_INVESTIGATOR

Karaman Training and Research Hospital

Locations

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Karaman Training and Research Hospital

Karaman, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Yurdagul Bahran Mustu, MD.

Role: CONTACT

Phone: +90 506 209 76 72

Email: [email protected]

Aynur Basaran, MD, Prof.

Role: CONTACT

Email: [email protected]

Facility Contacts

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Yurdagul Bahran Mustu, MD.

Role: primary

Aynur Basaran, MD, Prof.

Role: backup

Other Identifiers

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E-11095095-050.01.04-154055

Identifier Type: -

Identifier Source: org_study_id