Sensori-motor and Perceptual Functions of the PPC.

NCT ID: NCT03286686

Last Updated: 2026-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-22

Study Completion Date

2031-02-22

Brief Summary

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To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.

The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.

In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.

Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.

Detailed Description

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Conditions

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Healthy Volunteers Optic Ataxia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Experience 1

Group Type EXPERIMENTAL

point targets

Intervention Type BEHAVIORAL

In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.

Experience 2

Group Type EXPERIMENTAL

point targets

Intervention Type BEHAVIORAL

In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.

Experience 3

Group Type EXPERIMENTAL

tactile stimulation

Intervention Type BEHAVIORAL

In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.

Experience 4

Group Type EXPERIMENTAL

visual images

Intervention Type BEHAVIORAL

Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Experience 5

Group Type EXPERIMENTAL

visual images

Intervention Type BEHAVIORAL

Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Experience 6

Group Type EXPERIMENTAL

visual images

Intervention Type BEHAVIORAL

Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Interventions

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point targets

In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.

Intervention Type BEHAVIORAL

tactile stimulation

In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.

Intervention Type BEHAVIORAL

visual images

Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

All patients and healthy subjects:

* male and female, age from 18 to 75 years included
* normal vision or corrected vision
* covered by social security
* signed written informed consent

Patients:

* neurological injury in posterior parietal cortex supported by a cerebral MRI
* present optic ataxia symptoms Healthy subjects
* no known neurological injury

Exclusion Criteria

\- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Laure PISELLA, PhD

Role: PRINCIPAL_INVESTIGATOR

INSERM U1028 - Impact - CRNL

Locations

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U1028 INSERM - CNRS UMR 5292 Equipe ImpAct

Bron, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Laure PISELLA, PhD

Role: CONTACT

4 72 91 34 05 ext. +33

Facility Contacts

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Laure Pisella, PhD

Role: primary

4 72 91 34 05 ext. +33

Other Identifiers

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2017-A02562-51

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL17_0341

Identifier Type: -

Identifier Source: org_study_id

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