Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME

NCT ID: NCT04038125

Last Updated: 2020-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-22

Study Completion Date

2021-08-31

Brief Summary

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The objective of this study is to test the hypothesis that following the use of intravitreal dexamethasone implant for the treatment of DME, there will be an observable increase in the capillary density plexus as denoted by the quantitative assessment of the superficial capillary plexus on OCTA, as well as a decrease in size of the foveal avascular zone (FAZ).

Detailed Description

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Conditions

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Diabetic Macular Edema Diabetic Retinopathy Retinal Ischemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ozurdex Implant

Intravitreal injection of Ozurdex implant

Group Type OTHER

Ozurdex Drug Implant Product

Intervention Type DRUG

Intravitreal Ozurdex injection

Interventions

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Ozurdex Drug Implant Product

Intravitreal Ozurdex injection

Intervention Type DRUG

Other Intervention Names

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Dexamethasone

Eligibility Criteria

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Inclusion Criteria

1. Age ≥ 18 years and Older.
2. Diagnosis of diabetes mellitus (type 1 or type 2).
3. At least one eye meets the study eye criteria listed.
4. Visual Acuity 20/30 - 20/200 Snellen equivalent
5. Have received no previous treatment for diabetic macular edema,(treatment naïve)
6. Mild to Severe Non-proliferative Diabetic Retinopathy
7. Diabetic macular edema present on optical coherence tomography (OCT) central subfield: ≥ 300µm.
8. Able and willing to provide informed consent.

Exclusion Criteria

1. Have had any prior ocular treatment.
2. Have had prior retinal surgical ( i.e. Pars plana vitrectomy). 3 .Have any clinical evidence of proliferative diabetic retinopathy.

4\. Have a HBA1c of greater of 10%. 5. Evidence of Glaucoma or who are labeled glaucoma suspect at screening (defined as C/D \>/= 0.5 with correlated NFLA thinning or IOP\>25mmHg). 6. Have a contraindication to Ozurdex.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allergan

INDUSTRY

Sponsor Role collaborator

Retina Macula Specialists of Miami, LLC

OTHER

Sponsor Role lead

Responsible Party

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Diana Shechtman, OD FAAO

Principal Investigator - OD, FAAO

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Diana Shechtman, OD FAAO

Role: PRINCIPAL_INVESTIGATOR

Retina Macula Specialists of Miami, LLC

Locations

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Retina Macula Specialists of Miami, LLC

North Miami Beach, Florida, United States

Site Status RECRUITING

Retina Macula Specialists of Miami, LLC

South Miami, Florida, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Diana Shechtman, OD FAAO

Role: CONTACT

954-816-1038

Pamela Garcia, CCRC

Role: CONTACT

305-643-8871

Facility Contacts

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Joyce Gonzalez

Role: primary

305-655-0411

Pamela Garcia

Role: backup

306-643-8871

Joyce Gonzalez

Role: primary

305-666-8850

Pamela Garcia

Role: backup

305-643-8871

Other Identifiers

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LCH-0-012-019

Identifier Type: -

Identifier Source: org_study_id

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