The Effects of Intravitreal Ozurdex Implant in DME

NCT ID: NCT03475407

Last Updated: 2018-03-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2018-12-31

Brief Summary

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Intravitreal Ozurdex implant therapy improves visual outcome and OCT findings. The purpose of this study is that these results are correlated with the change of cytokine level known to be increased in DME patients.

Detailed Description

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Conditions

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Diabetic Macular Edema

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment Group

Ozurdex intravitreal injection

Group Type EXPERIMENTAL

Ozurdex intravitreal injection

Intervention Type DRUG

1. Ozurdex intravitreal injection and Antreior Chamber(AC) paracentesis at baseline
2. AC paracentesis at 6 wk
3. intravitreal Ozurdex injection and AC paracentesis at 18wk or 24wk

Interventions

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Ozurdex intravitreal injection

1. Ozurdex intravitreal injection and Antreior Chamber(AC) paracentesis at baseline
2. AC paracentesis at 6 wk
3. intravitreal Ozurdex injection and AC paracentesis at 18wk or 24wk

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients of Non Proliferative Diabetic Retinopathy(NPDR) with clinically significant macular edema(CSME)
* Patients with Proliferative Diabetic Retinopathy(PDR) with CSME where proliferative component has been adequately treated with laser photocoagulation
* Diabetic patients with cystoids macular edema
* Minimum central thickness on OCT not less than 300 microns
* BCVA 20/30\~20/320

Exclusion Criteria

* Patients with history of Anti-VEGF or steroid injection, any type of laser treatments, vitrectomy, cataract surgery within 6 months
* Patients with history of ocular hypertension or glaucoma
* Patients with media haze or pupillary non-dilation that does not allow good fundus photography, FFA and OCT
* Patients with macular ischemia on FFA
* Patients with active or suspected ocular or periocular infections including most viral diseases of the cornea and conjunctiva
* Patients whose posterior lens capsule is not intact.
* patients with known hypersensitivity to any components of this product.
* patients with vitreous hemorrhage
* patients who have systemic treatment effect on study results
* patients who enrolled other clinical study
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nune Eye Hospital, Seoul, Korea

OTHER

Sponsor Role lead

Responsible Party

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Oh Woong Kwon

Chief of retina center in Nune Eye Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Oh Woong Kwon, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Nune Eye Hospital

Locations

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Nune Eye Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Oh Woong Kwon, MD, Ph D

Role: CONTACT

+82+2+2086+7752

Facility Contacts

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Jin Hae Lee, MD

Role: primary

+82-10-2765-5303

Other Identifiers

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CRBF004

Identifier Type: -

Identifier Source: org_study_id

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