The Associations Between Dietary Choline, Genetics and Anxiety/Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-01

Study Completion Date

2019-10-03

Brief Summary

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The associations between dietary choline, genetics and anxiety/depression

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Detailed Description

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Choline, previously considered to be a vitamin, is an essential nutrient involved in a plethora of biological pathways. Choline status is thought to be associated with depression and anxiety, however, the lack of evidence regarding the exact mechanism of its action warrants further investigation. This study aims to explore the associations between dietary choline and depression and anxiety in healthy individuals and how these may differ according to genetics, specifically Phosphatidylethanolamine N-Methyltransferase gene involved in endogenous and exogenous choline metabolism. Establishing these associations could reinforce the need for future intervention trials that could in turn establish causality and determine the mechanistic effects of dietary choline and the PEMT gene activity on depression/anxiety

Conditions

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Choline Deficiency Anxiety Depression

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Overall healthy males
* pre-menopausal females of 18-50 years of age.

Exclusion Criteria

* Individuals with a current clinical diagnosis of anxiety and depression
* pregnant or lactating
* post-menopausal women
* individuals suffering with chronic disease (cardiovascular disease, type-2 diabetes mellitus and cancer)
* individuals using choline, lecithin or soy supplements,
* obese individuals with a Body Mass Index (BMI) \>30 kg/m2.

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes