Age-Related Changes in Sleep-Dependent Emotional Memory
NCT ID: NCT04141722
Last Updated: 2019-10-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2018-12-11
2020-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Sleep
Overnight sleep
Participant sent home to sleep overnight wearing PSG.
Wake
Wake
Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise.
Interventions
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Overnight sleep
Participant sent home to sleep overnight wearing PSG.
Wake
Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise.
Eligibility Criteria
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Inclusion Criteria
* Have no history of a sleep disorder
* Have no history of neurological disease or injury
* Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
* No history of chemotherapy
* Not be taking medications which effect sleep
* Habitually sleep more than 6 or more hours per night
* Be able to walk freely and independently
* Have normal to corrected-to-normal vision
18 Years
80 Years
ALL
Yes
Sponsors
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University of Massachusetts, Amherst
OTHER
Responsible Party
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Rebecca Spencer
Associate Professor
Principal Investigators
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Rebecca Spencer
Role: PRINCIPAL_INVESTIGATOR
University of Massachusetts, Amherst
Locations
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University of Massachusetts, Amherst
Amherst, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Dalgleish T, Werner-Seidler A. Disruptions in autobiographical memory processing in depression and the emergence of memory therapeutics. Trends Cogn Sci. 2014 Nov;18(11):596-604. doi: 10.1016/j.tics.2014.06.010. Epub 2014 Jul 21.
Ramirez S, Liu X, MacDonald CJ, Moffa A, Zhou J, Redondo RL, Tonegawa S. Activating positive memory engrams suppresses depression-like behaviour. Nature. 2015 Jun 18;522(7556):335-9. doi: 10.1038/nature14514.
Speer ME, Bhanji JP, Delgado MR. Savoring the past: positive memories evoke value representations in the striatum. Neuron. 2014 Nov 19;84(4):847-56. doi: 10.1016/j.neuron.2014.09.028. Epub 2014 Oct 30.
Baran B, Pace-Schott EF, Ericson C, Spencer RM. Processing of emotional reactivity and emotional memory over sleep. J Neurosci. 2012 Jan 18;32(3):1035-42. doi: 10.1523/JNEUROSCI.2532-11.2012.
Jones BJ, Schultz KS, Adams S, Baran B, Spencer RMC. Emotional bias of sleep-dependent processing shifts from negative to positive with aging. Neurobiol Aging. 2016 Sep;45:178-189. doi: 10.1016/j.neurobiolaging.2016.05.019. Epub 2016 May 27.
Leigland LA, Schulz LE, Janowsky JS. Age related changes in emotional memory. Neurobiol Aging. 2004 Sep;25(8):1117-24. doi: 10.1016/j.neurobiolaging.2003.10.015.
Charles ST, Mather M, Carstensen LL. Aging and emotional memory: the forgettable nature of negative images for older adults. J Exp Psychol Gen. 2003 Jun;132(2):310-24. doi: 10.1037/0096-3445.132.2.310.
Mather M, Carstensen LL. Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn Sci. 2005 Oct;9(10):496-502. doi: 10.1016/j.tics.2005.08.005.
Charles ST, Reynolds CA, Gatz M. Age-related differences and change in positive and negative affect over 23 years. J Pers Soc Psychol. 2001 Jan;80(1):136-51.
Mroczek DK, Kolarz CM. The effect of age on positive and negative affect: a developmental perspective on happiness. J Pers Soc Psychol. 1998 Nov;75(5):1333-49. doi: 10.1037//0022-3514.75.5.1333.
Other Identifiers
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