The PATHFINDER Study: A Feasibility Trial

NCT ID: NCT04016740

Last Updated: 2021-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-20

Study Completion Date

2020-07-07

Brief Summary

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The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery.

Detailed Description

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The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery.

Specific Aim 1: The feasibility of implementing multimodal general anesthesia strategy in the Operating Rooms (OR) Specific Aim 2: The feasibility of implementing EEG guided sedation until extubation in the Intensive Care Unit (ICU) Specific Aim 3: The enhancement of recovery after surgery (shorter ventilation time, ICU stay, hospital length of stay) Specific Aim 4: To estimate the effect size of decrease in postoperative day (POD) and postoperative cognitive dysfunction (POCD) to power future large randomized trials

Conditions

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Coronary Artery Disease Delirium

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SEQUENTIAL

2 roll-in patients followed by 20 patients in the interventional model.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Multimodal General Anesthesia

Intraoperative

The anesthesiologists involved in this study will be trained to infer differences in anti-nociception, unconsciousness movement and changes during other perioperative events by monitoring EEG. They will also be trained in titrating hypnotic and nociceptic medications based on changes in EEG.

1. Routine anesthetic induction
2. Bilateral Pectoro-interfascial block (PIFB) with 20 mL of 0.25% ropivacaine on either side of the sternum after anesthetic induction but before surgical incision
3. Ketamine (0.06 to 0.12 mg.kg/hr)
4. Remifentanil (0.05-0.2 mcg/kg/min)
5. Dexmedetomidine (0.2-1.0 mcg/kg/hr)
6. Rocuronium intermittent bolus (TOF)
7. Propofol infusion ± Sevoflurane titrated based on EEG monitoring

Postoperative

1. Standard pain management protocol
2. Dexmedetomidine infusion 0.2-1.4 mcg/kg/hr (EEG guided)
3. Infusion continued till extubation
4. Propofol infusion may be added/used for sedation based on the treating physician's discretion

Group Type EXPERIMENTAL

Ropivacaine

Intervention Type DRUG

Intraoperative bilateral PIFB block with 20 mL of 0.25% Ropivicaine on either side of the sternum after anesthetic induction but before surgical incision

Ketamine

Intervention Type DRUG

Intraoperative infusion

Remifentanil

Intervention Type DRUG

Intraoperative infusion

Dexmedetomidine

Intervention Type DRUG

Intraoperative infusion

Rocuronium

Intervention Type DRUG

Intraoperative intermittent bolus

Propofol

Intervention Type DRUG

Intraoperative infusion

Sevoflurane

Intervention Type DRUG

Intraoperative inhaled as needed

Dexmedetomidine

Intervention Type DRUG

Post-operative infusion

Propofol

Intervention Type DRUG

Post-operative infusion

EEG monitoring

Intervention Type DEVICE

Perioperative monitoring

Standard Practice with EEG monitoring

The initial 2 patients will receive standard anesthesia practice and perioperative EEG monitoring will be recorded to learn the patterns associated with our standard practice.

Group Type OTHER

EEG monitoring

Intervention Type DEVICE

Perioperative monitoring

Interventions

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Ropivacaine

Intraoperative bilateral PIFB block with 20 mL of 0.25% Ropivicaine on either side of the sternum after anesthetic induction but before surgical incision

Intervention Type DRUG

Ketamine

Intraoperative infusion

Intervention Type DRUG

Remifentanil

Intraoperative infusion

Intervention Type DRUG

Dexmedetomidine

Intraoperative infusion

Intervention Type DRUG

Rocuronium

Intraoperative intermittent bolus

Intervention Type DRUG

Propofol

Intraoperative infusion

Intervention Type DRUG

Sevoflurane

Intraoperative inhaled as needed

Intervention Type DRUG

Dexmedetomidine

Post-operative infusion

Intervention Type DRUG

Propofol

Post-operative infusion

Intervention Type DRUG

EEG monitoring

Perioperative monitoring

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age ≥ 60 years
2. Undergoing any of the following types of surgery with cardiopulmonary bypass limited to coronary artery bypass surgery (CABG), CABG+valve surgeries and isolated valve surgeries.

Exclusion Criteria

1. Preoperative left ventricular ejection fraction (LVEF) \<30%
2. Emergent surgery
3. Non-English speaking
4. Cognitive impairment as defined by total MoCA score \< 10
5. Currently enrolled in another interventional study that could impact the primary outcome, as determined by the PI
6. Significant visual impairment
7. Chronic opioid use for chronic pain conditions with tolerance (total dose of an opioid at or more than 30 mg morphine equivalent for more than one month within the past year)
8. Hypersensitivity to any of the study medications
9. Known history of alcohol (\> 2 drinks per day) or drug abuse Active (in the past year) history of alcohol abuse (≥5 drinks/day for men or ≥4 drinks/day for women) as determined by reviewing medical record and history given by the patient
10. Liver dysfunction (liver enzymes \> 4 times the baseline, all patients will have a baseline liver function test evaluation), history and examination suggestive of jaundice.
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beth Israel Deaconess Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Balachundhar Subramaniam

Associate Professor of Anesthesia

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Balachundhar Subramaniam, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Beth Israel Deaconess Medical Center

Locations

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Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Reference Type BACKGROUND

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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Reference Type BACKGROUND

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Reference Type DERIVED
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Other Identifiers

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2019P000407

Identifier Type: -

Identifier Source: org_study_id

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