A Clinical Comparison of Two Daily Disposable Soft Contact Lenses

NCT ID: NCT04005885

Last Updated: 2021-01-05

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-01

Study Completion Date

2019-11-30

Brief Summary

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This double-masked, randomized, bilateral, crossover, direct refit study compared the clinical performance of two daily disposable contact lenses (somofilcon A and stenfilcon A) when fitted to existing wearers of comfilcon A monthly lenses.

Detailed Description

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This double-masked (subject and investigator), randomized, bilateral, crossover, direct refit study compared the clinical performance of two daily disposable test contact lenses (somofilcon A and stenfilcon A) when fitted to existing wearers of comfilcon A monthly lenses. After a month of re-useable lens wear in the comfilcon A lenses, subjects were randomized to wear each daily disposable lens type for one week.

Conditions

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Myopia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Investigators
Subjects and investigators will be masked to the study lenses - lenses will be overlabelled.

Study Groups

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somofilcon A then stenfilcon A contact lens

Participants were fitted with comfilcon A lens on a daily wear, reusable basis for 1 month, then randomized to wear somofilcon A daily disposable test lens for 1 week of daily wear and stenfilcon A daily disposable test lens for 1 week of daily wear.

Group Type EXPERIMENTAL

comfilcon A

Intervention Type DEVICE

Contact Lens

somofilcon A

Intervention Type DEVICE

daily disposable contact lens

stenfilcon A

Intervention Type DEVICE

daily disposable contact lens

stenfilcon A then somofilcon A contact lens

Participants were fitted with comfilcon A lens on a daily wear, reusable basis for 1 month, then randomized to wear stenfilcon A daily disposable test lens for 1 week of daily wear and somofilcon A daily disposable test lens for 1 week of daily wear.

Group Type EXPERIMENTAL

comfilcon A

Intervention Type DEVICE

Contact Lens

somofilcon A

Intervention Type DEVICE

daily disposable contact lens

stenfilcon A

Intervention Type DEVICE

daily disposable contact lens

Interventions

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comfilcon A

Contact Lens

Intervention Type DEVICE

somofilcon A

daily disposable contact lens

Intervention Type DEVICE

stenfilcon A

daily disposable contact lens

Intervention Type DEVICE

Other Intervention Names

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Control Lens somofilcon A daily disposable test lens Test lens 1 stenfilcon A daily disposable test lens Test lens 2

Eligibility Criteria

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Inclusion Criteria

* Subjects will only be eligible for the study if:
* They are between 18 and 40 years of age (inclusive).
* They understand their rights as a research subject and are willing and able to sign a Statement of Informed Consent.
* They are willing and able to follow the protocol.
* They are an existing soft reusable spherical contact lens wearer in both eyes.
* They have a contact lens spherical prescription between -0.50 to -6.00D (inclusive) based on the ocular refraction.
* They have a cylindrical correction of -0.875DC or less in each eye based on the ocular refraction
* They own a wearable pair of spectacles and wear them on the day of the initial visit.
* They have distance high contrast logMAR visual acuity of 0.2 or better in each eye with their habitual spectacles.
* They agree not to participate in other clinical research for the duration of the study.

Exclusion Criteria

* They have an ocular disorder which would normally contra-indicate contact lens wear.
* They have a systemic disorder which would normally contra-indicate contact lens wear.
* They are using any topical medication such as eye drops or ointment.
* They are aphakic.
* They have had corneal refractive surgery.
* They have any corneal distortion resulting from previous hard or rigid lens wear or have keratoconus.
* They are pregnant or breastfeeding.
* They have any infectious disease which would, in the opinion of the investigator, contraindicate contact lens wear or pose a risk to study personnel; or they have any immunosuppressive disease (e.g. HIV), or a history of anaphylaxis or severe allergic reaction.
* They have taken part in any other contact lens or care solution clinical trial or research, within two weeks prior to starting this study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CooperVision, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Carole Maldonado-Codina, PhD, MCOptom, FAAO, FBCLA

Role: PRINCIPAL_INVESTIGATOR

Eurolens Research

Locations

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Eurolens Research - The University of Manchester

Manchester, , United Kingdom

Site Status

Countries

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United Kingdom

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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EX-MKTG-100

Identifier Type: -

Identifier Source: org_study_id

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