Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit
NCT ID: NCT04004091
Last Updated: 2020-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
42 participants
INTERVENTIONAL
2019-03-01
2019-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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24-Day Spermine Group
Subjects are given prenatal spermine (20 mg per body weight) during 24 days of pregnancy. On day 24 pregnancy is terminated and intestinal tissue sample is taken to be examined.
Spermine
Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism and development.
26-Day Spermine Group
Subjects are given prenatal spermine (20 mg per body weight) during 26 days of pregnancy. On day 26 pregnancy is terminated and intestinal tissue sample is taken to be examined.
Spermine
Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism and development.
28-Day Spermine Group
Subjects are given prenatal spermine (20 mg per body weight) during 28 days of pregnancy. On day 28 pregnancy is terminated and intestinal tissue sample is taken to be examined.
Spermine
Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism and development.
24-Day Non Spermine Group
Subjects are not given any intervention. On day 24 pregnancy is terminated and intestinal tissue sample is taken to be examined.
No interventions assigned to this group
26-Day Non Spermine Group
Subjects are not given any intervention. On day 26 pregnancy is terminated and intestinal tissue sample is taken to be examined.
No interventions assigned to this group
28-Day Non Spermine Group
Subjects are not given any intervention. On day 28 pregnancy is terminated and intestinal tissue sample is taken to be examined.
No interventions assigned to this group
Interventions
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Spermine
Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism and development.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Intestinal tissue of fetal rabbit, in which the parent died before termination
24 Days
28 Days
ALL
Yes
Sponsors
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dr. Riana Pauline Tamba, SpB(K)BA
OTHER
Responsible Party
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dr. Riana Pauline Tamba, SpB(K)BA
Consultant Pediatric Surgeon
Locations
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Dr. Cipto Mangunkusumo National Hospital
Jakarta Pusat, Jakarta Special Capital Region, Indonesia
Countries
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References
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van Wettere WH, Willson NL, Pain SJ, Forder RE. Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics. Animal. 2016 Oct;10(10):1655-9. doi: 10.1017/S1751731116000446. Epub 2016 Mar 21.
Peulen O, Gharbi M, Powroznik B, Dandrifosse G. Differential effect of dietary spermine on alkaline phosphatase activity in jejunum and ileum of unweaned rats. Biochimie. 2004 Jul;86(7):487-93. doi: 10.1016/j.biochi.2004.06.002.
Peulen O, Dandrifosse G. Spermine-induced maturation in wistar rat intestine: a cytokine-dependent mechanism. J Pediatr Gastroenterol Nutr. 2004 May;38(5):524-32. doi: 10.1097/00005176-200405000-00012.
Greco S, Niepceron E, Hugueny I, George P, Louisot P, Biol MC. Dietary spermidine and spermine participate in the maturation of galactosyltransferase activity and glycoprotein galactosylation in rat small intestine. J Nutr. 2001 Jul;131(7):1890-7. doi: 10.1093/jn/131.7.1890.
Peulen O, Pirlet C, Klimek M, Goffinet G, Dandrifosse G. Comparison between the natural postnatal maturation and the spermine-induced maturation of the rat intestine. Arch Physiol Biochem. 1998 Feb;106(1):46-55. doi: 10.1076/apab.106.1.46.4392.
Wery I, Deloyer P, Dandrifosse G. Effects of a single dose of orally-administered spermine on the intestinal development of unweaned rats. Arch Physiol Biochem. 1996;104(2):163-72. doi: 10.1076/apab.104.2.163.12886.
Harada E, Hashimoto Y, Syuto B. Orally administered spermine induces precocious intestinal maturation of macromolecular transport and disaccharidase development in suckling rats. Comp Biochem Physiol A Physiol. 1994 Nov;109(3):667-73. doi: 10.1016/0300-9629(94)90208-9.
Other Identifiers
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tight junction, spermine
Identifier Type: -
Identifier Source: org_study_id
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